eF-site ID 1lwc-A PDB Code 1lwc Chain A click to enlarge Title CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE Classification TRANSFERASE Compound HIV-1 REVERSE TRANSCRIPTASE Source null (POL_HV1H2) Sequence A:  PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEK EGKISKIGPENPYNTPVFAKLVDFRELNKRTQDFWEVQLG IPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIP SINNPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQN PDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLT TPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN DIQKLVGKLNWASQIYPGIKVRQLXKLLRGTKALTEVIPL TEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG QWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKI TTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWE FVNTPPLVKLWYQLEKEPIVGAETFYVDAGYVTNRGRQKV VTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQP DQSESELVNQIIEQLIKKEKVYLAWVP Description Functional site 1) chain A residue 461 type sequence R description BINDING SITE FOR RESIDUE PO4 A 1300 source : AC1 2) chain A residue 436 type sequence G description BINDING SITE FOR RESIDUE PO4 A 1301 source : AC2 3) chain A residue 437 type sequence A description BINDING SITE FOR RESIDUE PO4 A 1301 source : AC2 4) chain A residue 438 type sequence E description BINDING SITE FOR RESIDUE PO4 A 1301 source : AC2 5) chain A residue 460 type sequence N description BINDING SITE FOR RESIDUE PO4 A 1301 source : AC2 6) chain A residue 461 type sequence R description BINDING SITE FOR RESIDUE PO4 A 1301 source : AC2 7) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 8) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 9) chain A residue 103 type sequence K description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 10) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 11) chain A residue 179 type sequence V description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 12) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 13) chain A residue 188 type sequence Y description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 14) chain A residue 190 type sequence G description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 15) chain A residue 235 type sequence H description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 16) chain A residue 236 type sequence P description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 17) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE NVP A 999 source : AC3 18) chain A residue 432 type SITE sequence E description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 19) chain A residue 271 type SITE sequence Y description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7 20) chain A residue 277 type SITE sequence R description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7 21) chain A residue 333 type SITE sequence G description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI8

Display surface Download Links