eF-site ID 1lrt-C
PDB Code 1lrt
Chain C

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Title CRYSTAL STRUCTURE OF TERNARY COMPLEX OF TRITRICHOMONAS FOETUS INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE: STRUCTURAL CHARACTERIZATION OF NAD+ SITE IN MICROBIAL ENZYME
Classification OXIDOREDUCTASE
Compound INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE
Source Tritrichomonas foetus (Trichomonas foetus) (Tritrichomonas suis) (IMDH_TRIFO)
Sequence C:  AKYYNEPCHTFNEYLLIPGLSTVDCIPSNVNLSTPLVKFQ
KGQQSEINLKIPLVSAIMQSVSGEKMAIALAREGGISFIF
GSQSIESQAAMVHAVKNFKRYLVGAGINTRDFRERVPALV
EAGADVLCIDSSDGFSEWQKITIGWIRDKYGDKVKVGAGN
IVDGEGFRYLADAGADFIKIGIGGGSICEQKGIGRGQATA
VIDVVAERNKYFEETGIYIPVCSDGGIVYDYHMTLALAMG
ADFIMLGRYFARFEESPTRKVTINGSVMKEYWGEGSSRAR
NWDSYVPYAGKLKDNVEASLNKVKSTMCNCGALTIPQLQS
KAKITLVSSVSIVE
Description (1)  INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (E.C.1.1.1.205)


Functional site
1) chain C
residue 319
type ACT_SITE
sequence C
description Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:12235158, ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI1
2) chain C
residue 20
type BINDING
sequence G
description in other chain => ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI3
3) chain C
residue 22
type BINDING
sequence S
description in other chain => ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI3
4) chain C
residue 314
type BINDING
sequence G
description in other chain => ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI3
5) chain C
residue 316
type BINDING
sequence G
description in other chain => ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI3
6) chain C
residue 319
type BINDING
sequence C
description in other chain => ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI3
7) chain C
residue 460
type BINDING
sequence N
description in other chain => ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI3
8) chain C
residue 261
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI4
9) chain C
residue 312
type BINDING
sequence G
description
source Swiss-Prot : SWS_FT_FI4
10) chain C
residue 317
type BINDING
sequence S
description
source Swiss-Prot : SWS_FT_FI4
11) chain C
residue 358
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI4
12) chain C
residue 381
type BINDING
sequence G
description
source Swiss-Prot : SWS_FT_FI4
13) chain C
residue 405
type BINDING
sequence Y
description
source Swiss-Prot : SWS_FT_FI4
14) chain C
residue 264
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI5
15) chain C
residue 266
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI5
16) chain C
residue 485
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:12549902
source Swiss-Prot : SWS_FT_FI5

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