|
|
eF-site ID
|
1lqb-ABCD |
|
PDB Code
|
1lqb |
|
Chain
|
A, B, C, D |
|
click to enlarge
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|
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Title
|
Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex |
|
Classification
|
GENE REGULATION |
|
Compound
|
Elongin B |
|
Source
|
Homo sapiens (Human) (HIF1A_HUMAN) |
|
|
Sequence
|
A: |
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPD
EQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR
ADDTFEALCIEPFSSPPELPDVMK
|
| B: |
MYVKLISSDGHEFIVKREHALTSGTIKAMLSGPNEVNFRE
IPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELL
MAANFLDC
|
| C: |
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPT
LPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSL
NVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI
VRSLYEDLEDHPNVQKDLERLTQERIAHQR
|
| D: |
EMLAXYIPMDDDFQLRSF
|
|
|
Description
|
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Functional site
|
|
|
1)
|
chain |
A |
| residue |
73 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE SO4 A 801
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
74 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE SO4 A 801
|
| source |
: AC1
|
|
|
3)
|
chain |
D |
| residue |
564 |
| type |
MOD_RES |
| sequence |
X
|
| description |
4-hydroxyproline => ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:25974097
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
D |
| residue |
576 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by PLK3 => ECO:0000269|PubMed:20889502
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|