eF-site ID 1lpq-ABC PDB Code 1lpq Chain A, B, C click to enlarge Title Human DNA Topoisomerase I (70 Kda) In Non-Covalent Complex With A 22 Base Pair DNA Duplex Containing an 8-oxoG Lesion Classification ISOMERASE/DNA Compound 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*(8OG)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3' Source Homo sapiens (Human) (1LPQ) Sequence A:  KWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFY YDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKD WRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSK EEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLF RGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKW KEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDW QKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYF IDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQ EYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPE DDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQ LKELTAPDENIPAKILSYNRANRAVAILCNHQEKSMMNLQ TKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKK KAVQRLEEQLMKLEVQATDREENKQIALGTSKLNFLDPRI TVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF B:  AAAAAGACTTXGAAAAATTTTT C:  AAAAATTTTTCCAAGTCTTTTT Description Functional site 1) chain A residue 336 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 2) chain A residue 316 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 3) chain A residue 364 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 4) chain A residue 412 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 5) chain A residue 443 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 6) chain A residue 501 type SITE sequence T description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 7) chain A residue 532 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 8) chain A residue 574 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 9) chain A residue 632 type SITE sequence H description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 10) chain A residue 650 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 11) chain A residue 280 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 506 type MOD_RES sequence S description Phosphoserine; by CK2 => ECO:0000269|PubMed:23185622 source Swiss-Prot : SWS_FT_FI4 13) chain A residue 204 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 14) chain A residue 549 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 15) chain A residue 642 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 16) chain A residue 700 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 17) chain A residue 712 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 18) chain A residue 723 type ACT_SITE sequence F description O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000255|PROSITE-ProRule:PRU10130, ECO:0000269|PubMed:10841763, ECO:0000269|PubMed:12426403, ECO:0000269|PubMed:12533542, ECO:0000269|PubMed:15165849, ECO:0000269|PubMed:15801827, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:9488644 source Swiss-Prot : SWS_FT_FI1

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