eF-site ID 1lna-E PDB Code 1lna Chain E click to enlarge Title A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN Classification METALLOPROTEASE Compound THERMOLYSIN Source (THER_BACTH) Sequence E:  ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGDGIF TYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVT YDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSEM VYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNE SGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGD SLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKA AYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSN FSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK Description Functional site 1) chain E residue 166 type sequence E description source : CO0 2) chain E residue 142 type sequence H description source : CO0 3) chain E residue 146 type sequence H description source : CO0 4) chain E residue 112 type sequence N description BINDING SITE FOR RESIDUE VAL E 1321 source : AC1 5) chain E residue 113 type sequence A description BINDING SITE FOR RESIDUE VAL E 1321 source : AC1 6) chain E residue 143 type sequence E description BINDING SITE FOR RESIDUE VAL E 1321 source : AC1 7) chain E residue 203 type sequence R description BINDING SITE FOR RESIDUE VAL E 1321 source : AC1 8) chain E residue 111 type sequence N description BINDING SITE FOR RESIDUE LYS E 1322 source : AC2 9) chain E residue 112 type sequence N description BINDING SITE FOR RESIDUE LYS E 1322 source : AC2 10) chain E residue 231 type sequence H description BINDING SITE FOR RESIDUE LYS E 1322 source : AC2 11) chain E residue 142 type sequence H description BINDING SITE FOR RESIDUE CO E 900 source : AC3 12) chain E residue 146 type sequence H description BINDING SITE FOR RESIDUE CO E 900 source : AC3 13) chain E residue 166 type sequence E description BINDING SITE FOR RESIDUE CO E 900 source : AC3 14) chain E residue 138 type sequence D description BINDING SITE FOR RESIDUE CA E 901 source : AC4 15) chain E residue 177 type sequence E description BINDING SITE FOR RESIDUE CA E 901 source : AC4 16) chain E residue 185 type sequence D description BINDING SITE FOR RESIDUE CA E 901 source : AC4 17) chain E residue 187 type sequence E description BINDING SITE FOR RESIDUE CA E 901 source : AC4 18) chain E residue 190 type sequence E description BINDING SITE FOR RESIDUE CA E 901 source : AC4 19) chain E residue 177 type sequence E description BINDING SITE FOR RESIDUE CA E 902 source : AC5 20) chain E residue 183 type sequence N description BINDING SITE FOR RESIDUE CA E 902 source : AC5 21) chain E residue 185 type sequence D description BINDING SITE FOR RESIDUE CA E 902 source : AC5 22) chain E residue 190 type sequence E description BINDING SITE FOR RESIDUE CA E 902 source : AC5 23) chain E residue 57 type sequence D description BINDING SITE FOR RESIDUE CO E 903 source : AC6 24) chain E residue 59 type sequence D description BINDING SITE FOR RESIDUE CO E 903 source : AC6 25) chain E residue 61 type sequence Q description BINDING SITE FOR RESIDUE CO E 903 source : AC6 26) chain E residue 193 type sequence Y description BINDING SITE FOR RESIDUE CA E 904 source : AC7 27) chain E residue 194 type sequence T description BINDING SITE FOR RESIDUE CA E 904 source : AC7 28) chain E residue 197 type sequence I description BINDING SITE FOR RESIDUE CA E 904 source : AC7 29) chain E residue 200 type sequence D description BINDING SITE FOR RESIDUE CA E 904 source : AC7 30) chain E residue 216 type sequence H description BINDING SITE FOR RESIDUE DMS E 320 source : AC8 31) chain E residue 218 type sequence S description BINDING SITE FOR RESIDUE DMS E 320 source : AC8 32) chain E residue 251 type sequence Y description BINDING SITE FOR RESIDUE DMS E 320 source : AC8 33) chain E residue 139-148 type prosite sequence VVAHELTHAV description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV source prosite : PS00142 34) chain E residue 291 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 35) chain E residue 289 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI1 36) chain E residue 293 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI1

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