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eF-site ID
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1lm8-BCHV |
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PDB Code
|
1lm8 |
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Chain
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B, C, H, V |
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click to enlarge
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Title
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Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex |
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Classification
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TRANSCRIPTION |
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Compound
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ELONGIN B |
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Source
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Homo sapiens (Human) (HIF1A_HUMAN) |
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Sequence
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B: |
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPD
EQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR
ADDTFEALCIEPFSSPPELPDVMKPQ
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| C: |
MYVKLISSDGHEFIVKREHALTSGTIKAMLSGPNEVNFRE
IPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELL
MAANFLDC
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| H: |
MLAXYIPMDDDFQLR
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| V: |
RPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYP
TLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPS
LNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLD
IVRSLYEDLEDHPNVQKDLERLTQERIAHQ
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Description
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Functional site
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1)
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chain |
H |
| residue |
564 |
| type |
MOD_RES |
| sequence |
X
|
| description |
4-hydroxyproline => ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:25974097
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
|
chain |
B |
| residue |
84 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0000250|UniProtKB:P62869
|
| source |
Swiss-Prot : SWS_FT_FI2
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