eF-site ID 1lhf-HIL PDB Code 1lhf Chain H, I, L click to enlarge Title HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BORO-HOMOLYS-OH Classification COMPLEX (SERINE PROTEASE/INHIBITOR) Compound ALPHA-THROMBIN Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence H:  IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIV ERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKK WIQKVIDQF I:  GDFEEIP L:  ADCGLRPLFEKKSLEDKTERELLESY Description (1)  ALPHA-THROMBIN, HIRUDIN, AC-(D)PHE-PRO-BOROHOMOLYS-OH Functional site 1) chain H residue 57 type sequence H description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 2) chain H residue 60 type sequence L description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 3) chain H residue 99 type sequence L description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 4) chain H residue 174 type sequence I description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 5) chain H residue 189 type sequence D description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 6) chain H residue 190 type sequence A description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 7) chain H residue 191 type sequence C description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 8) chain H residue 192 type sequence E description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 9) chain H residue 193 type sequence G description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 10) chain H residue 194 type sequence D description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 11) chain H residue 195 type sequence S description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 12) chain H residue 213 type sequence V description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 13) chain H residue 214 type sequence S description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 14) chain H residue 215 type sequence W description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 15) chain H residue 216 type sequence G description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 16) chain H residue 226 type sequence G description BINDING SITE FOR RESIDUE DI4 H 400 source : AC1 17) chain H residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 source Swiss-Prot : SWS_FT_FI2 18) chain H residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 19) chain H residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135 20) chain H residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 21) chain H residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 22) chain H residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1

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