eF-site ID 1lgc-ABCDEFHIJ PDB Code 1lgc Chain A, B, C, D, E, F, H, I, J click to enlarge Title INTERACTION OF A LEGUME LECTIN WITH THE N2 FRAGMENT OF HUMAN LACTOTRANSFERRIN OR WITH THE ISOLATED BIANTENNARY GLYCOPEPTIDE: ROLE OF THE FUCOSE MOIETY Classification LECTIN Compound LEGUME ISOLECTIN II (ALPHA CHAIN) Source null (LEC2_LATOC) Sequence A:  TETTSFSITKFGPDQPNLIFQGDGYTTKERLTLTKAVRNT VGRALYSSPIHIWDSKTGNVANFVTSFTFVIDAPNSYNVA DGFTFFIAPVDTKPQTGGGYLGVFNSKDYDKTSQTVAVEF DTFYNTAWDPSNGDRHIGIDVNSIKSINTKSWKLQNGKEA NVVIAFNGATNVLTVSLTYPN B:  ETSYTLNEVVPLKEFVPEWVRIGFSATTGAEFAAHEVLSW YFNSELSVTSS C:  TETTSFSITKFGPDQPNLIFQGDGYTTKERLTLTKAVRNT VGRALYSSPIHIWDSKTGNVANFVTSFTFVIDAPNSYNVA DGFTFFIAPVDTKPQTGGGYLGVFNSKDYDKTSQTVAVEF DTFYNTAWDPSNGDRHIGIDVNSIKSINTKSWKLQNGKEA NVVIAFNGATNVLTVSLTYPN D:  ETSYTLNEVVPLKEFVPEWVRIGFSATTGAEFAAHEVLSW YFNSELSV E:  TETTSFSITKFGPDQPNLIFQGDGYTTKERLTLTKAVRNT VGRALYSSPIHIWDSKTGNVANFVTSFTFVIDAPNSYNVA DGFTFFIAPVDTKPQTGGGYLGVFNSKDYDKTSQTVAVEF DTFYNTAWDPSNGDRHIGIDVNSIKSINTKSWKLQNGKEA NVVIAFNGATNVLTVSLTYPN F:  TSYTLNEVVPLKEFVPEWVRIGFSATTGAEFAAHEVLSWY FNSELSV H:  N I:  N J:  NQ Description (1)  LEGUME ISOLECTIN II (LOL II) COMPLEXED WITH A HUMAN LACTOTRANSFERRIN GLYCOPEPTIDE Functional site 1) chain A residue 99 type sequence G description MANNOSE (MAN 4) BINDING SITE 1 source : A1 2) chain A residue 81 type sequence D description MANNOSE (MAN 4) BINDING SITE 1 source : A1 3) chain A residue 125 type sequence N description MANNOSE (MAN 4) BINDING SITE 1 source : A1 4) chain B residue 29 type sequence G description MANNOSE (MAN 4) BINDING SITE 1 source : A1 5) chain B residue 30 type sequence A description MANNOSE (MAN 4) BINDING SITE 1 source : A1 6) chain B residue 31 type sequence E description MANNOSE (MAN 4) BINDING SITE 1 source : A1 7) chain B residue 32 type sequence F description FUCOSE (FUC 1) BINDING CAVITY 1 source : B1 8) chain B residue 31 type sequence E description FUCOSE (FUC 1) BINDING CAVITY 1 source : B1 9) chain C residue 99 type sequence G description MANNOSE (MAN 4) BINDING SITE 2 source : A2 10) chain C residue 81 type sequence D description MANNOSE (MAN 4) BINDING SITE 2 source : A2 11) chain C residue 125 type sequence N description MANNOSE (MAN 4) BINDING SITE 2 source : A2 12) chain D residue 29 type sequence G description MANNOSE (MAN 4) BINDING SITE 2 source : A2 13) chain D residue 30 type sequence A description MANNOSE (MAN 4) BINDING SITE 2 source : A2 14) chain D residue 31 type sequence E description MANNOSE (MAN 4) BINDING SITE 2 source : A2 15) chain D residue 32 type sequence F description FUCOSE (FUC 1) BINDING CAVITY 2 source : B2 16) chain D residue 31 type sequence E description FUCOSE (FUC 1) BINDING CAVITY 2 source : B2 17) chain E residue 99 type sequence G description MANNOSE (MAN 4) BINDING SITE 3 source : A3 18) chain E residue 81 type sequence D description MANNOSE (MAN 4) BINDING SITE 3 source : A3 19) chain E residue 125 type sequence N description MANNOSE (MAN 4) BINDING SITE 3 source : A3 20) chain F residue 29 type sequence G description MANNOSE (MAN 4) BINDING SITE 3 source : A3 21) chain F residue 30 type sequence A description MANNOSE (MAN 4) BINDING SITE 3 source : A3 22) chain F residue 31 type sequence E description MANNOSE (MAN 4) BINDING SITE 3 source : A3 23) chain F residue 32 type sequence F description FUCOSE (FUC 1) BINDING CAVITY 3 source : B3 24) chain F residue 31 type sequence E description FUCOSE (FUC 1) BINDING CAVITY 3 source : B3 25) chain A residue 116-122 type prosite sequence VAVEFDT description LECTIN_LEGUME_BETA Legume lectins beta-chain signature. VAVEFDT source prosite : PS00307 26) chain B residue 16-25 type prosite sequence VPEWVRIGFS description LECTIN_LEGUME_ALPHA Legume lectins alpha-chain signature. VPEWVRIGFS source prosite : PS00308 27) chain A residue 125 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 28) chain A residue 129 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 29) chain A residue 136 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 30) chain C residue 119 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 31) chain C residue 121 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 32) chain C residue 123 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1 33) chain C residue 125 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 34) chain C residue 129 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 35) chain C residue 136 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 36) chain E residue 119 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 37) chain E residue 121 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 38) chain E residue 123 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1 39) chain E residue 125 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 40) chain E residue 129 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 41) chain E residue 136 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 42) chain A residue 119 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 43) chain A residue 121 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 44) chain A residue 123 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1

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