eF-site ID 1lew-AB PDB Code 1lew Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A Classification TRANSFERASE Compound Mitogen-activated protein kinase 14 Source Mus musculus (Mouse) (MEF2A_HUMAN) Sequence A:  RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDT KTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVI GLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL KILDFGLARVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM AELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE SARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDS DKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLL IDEWKSLTYDEVISFVPPPLD B:  KPDLRVVIPP Description Functional site 1) chain A residue 168 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 30 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 3) chain A residue 53 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 16 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:Q16539 source Swiss-Prot : SWS_FT_FI4 5) chain A residue 53 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:Q16539 source Swiss-Prot : SWS_FT_FI5 6) chain A residue 152 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:Q16539 source Swiss-Prot : SWS_FT_FI5 7) chain A residue 30-54 type prosite sequence VGSGAYGSVCAAFDTKTGHRVAVKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktghrv.........AVKK source prosite : PS00107 8) chain A residue 59-162 type prosite sequence FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEE FNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGL KYIHSADIIHRDLKPSNLAVNEDC description MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC source prosite : PS01351 9) chain A residue 323 type MOD_RES sequence Y description Phosphotyrosine; by ZAP70 => ECO:0000250|UniProtKB:Q16539 source Swiss-Prot : SWS_FT_FI8

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