eF-site ID 1ldc-B PDB Code 1ldc Chain B click to enlarge Title X-RAY STRUCTURE OF TWO COMPLEXES OF THE Y143F FLAVOCYTOCHROME B2 MUTANT CRYSTALLIZED IN THE PRESENCE OF LACTATE OR PHENYL-LACTATE Classification OXIDOREDUCTASE Compound L-LACTATE DEHYDROGENASE Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (CYB2_YEAST) Sequence B:  TKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAW AFYSSGANDEVTHRENHNAYHRIFFKPKILVDVRKVDIST DMLGSHVDVPFYVSATALCKLGNPLEGEKDVARGCGQGVT KVPQMISTLASCSPEEIIEAAPSDKQIQWYQLYVNSDRKI TDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKFIDPS LTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVV LSNHGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVD GGVRRGTDVLKALCLGAKGVGLGRPFLYANSCYGRNGVEK AIEILRDEIEMSMRLLGVTSIAELKPDLLDLSTLKARTVG VPNDVLYNEVYEGPTLTEFEDA Description Functional site 1) chain B residue 143 type sequence F description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 2) chain B residue 144 type sequence Y description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 3) chain B residue 195 type sequence S description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 4) chain B residue 196 type sequence A description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 5) chain B residue 197 type sequence T description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 6) chain B residue 198 type sequence A description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 7) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 8) chain B residue 252 type sequence Q description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 9) chain B residue 254 type sequence Y description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 10) chain B residue 280 type sequence T description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 11) chain B residue 349 type sequence K description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 12) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 13) chain B residue 374 type sequence G description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 14) chain B residue 376 type sequence R description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 15) chain B residue 409 type sequence D description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 16) chain B residue 410 type sequence G description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 17) chain B residue 411 type sequence G description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 18) chain B residue 413 type sequence R description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 19) chain B residue 432 type sequence G description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 20) chain B residue 433 type sequence R description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 21) chain B residue 436 type sequence L description BINDING SITE FOR RESIDUE FMN B 570 source : AC4 22) chain B residue 143 type sequence F description BINDING SITE FOR RESIDUE PYR B 580 source : AC5 23) chain B residue 198 type sequence A description BINDING SITE FOR RESIDUE PYR B 580 source : AC5 24) chain B residue 254 type sequence Y description BINDING SITE FOR RESIDUE PYR B 580 source : AC5 25) chain B residue 289 type sequence R description BINDING SITE FOR RESIDUE PYR B 580 source : AC5 26) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE PYR B 580 source : AC5 27) chain B residue 376 type sequence R description BINDING SITE FOR RESIDUE PYR B 580 source : AC5 28) chain B residue 254 type catalytic sequence Y description 102 source MCSA : MCSA2 29) chain B residue 282 type catalytic sequence D description 102 source MCSA : MCSA2 30) chain B residue 373 type catalytic sequence H description 102 source MCSA : MCSA2 31) chain B residue 143 type BINDING sequence F description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 32) chain B residue 195 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 33) chain B residue 228 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 34) chain B residue 252 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 35) chain B residue 254 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 36) chain B residue 280 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 37) chain B residue 349 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 38) chain B residue 373 type BINDING sequence H description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 39) chain B residue 376 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 40) chain B residue 409 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 41) chain B residue 432 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11914072, ECO:0000269|PubMed:2329585, ECO:0007744|PDB:1FCB, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI3 42) chain B residue 139 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:11914072, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI4 43) chain B residue 296 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11914072, ECO:0007744|PDB:1KBI source Swiss-Prot : SWS_FT_FI4 44) chain B residue 373 type ACT_SITE sequence H description Proton acceptor => ECO:0000305|PubMed:17563122 source Swiss-Prot : SWS_FT_FI1

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