eF-site ID 1l9u-JKLMNQ PDB Code 1l9u Chain J, K, L, M, N, Q click to enlarge Title THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION Classification TRANSCRIPTION Compound RNA POLYMERASE, ALPHA SUBUNIT Source ORGANISM_SCIENTIFIC: Thermus aquaticus; Sequence J:  LKAPVFTATTQGDHYGEFVLEPLERGFGVTLGNPLRRILL SSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIILNLKEL VVRFLDPKMASTTLILRAEGPKEVRAGDFTPSADVEIMNP DLHIATLEEGGKLYMEVRVDRGVGYVPAERHGIKDRINAI PVDAIFSPVRRVAFQVEDTRLGQRTDLDKLTLRIWTDGSV TPLEALNQAVAILKEHLNYFANPE K:  LKAPVFTATTQGDHYGEFVLEPLERGFGVTLGNPLRRILL SSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIILNLKEL VVRFLDPKMASTTLILRAEGPKEVRAGDFTPSADVEIMNP DLHIATLEEGGKLYMEVRVDRGVGYVPAERHGIKDRINAI PVDAIFSPVRRVAFQVEDTRLGQRTDLDKLTLRIWTDGSV TPLEALNQAVAILKEHLNYF L:  EIKRFGRIREVIPLPPLTEIQVESYKKALQADVPPEKREN VGIQAAFKETFPIEEGLVLDFLEYRIGDPPFSQDECREKD LTYQAPLYARLQLIHKDTGLIKEDEVFLGHLPLMTEDGSF IINGADRVIVSQIHRSPGVYFTPDPARPGRYIASIIPLPK RGPWIDLEVEASGVVTMKVNKRKFPLVLLLRVLGYDQETL VRELSGLLDEAVLAMRPEEAMVRLFTLLRPGLAYLFGLLA DPKRYDLGEAGRYKAEEKLGVGLSGRTLVFKDEVFLPTLR YLFALTAGVPGHEVDDIDHLGNRRIRTVGELMADQFRVGL ARLARGVRERMVMGSPDTLTPAKLVNSRPLEAALREFFSR SQLSQFKDETNPLSSLRHKRRISALGPGGLTRERAGFDVR DVHRTHYGRICPVETPEGANIGLITSLAAYARVDALGFIR TPYRRVKNGVVTEEVVYMTASEEDRYTIAQANTPLEGDRI ATDRVVARRRGEPVIVAPEEVEFMDVSPKQVFSLNTNLIP FLEHDDANRALMGSNMQTQAVPLIRAQAPVVMTGLEERVV RDSLAALYAEEDGEVVKVDGTRIAVRYEDGRLVHPLRRYA RSNQGTAFDQRPRVRVGQRVDLLADGPASEEGFLALGQNV LVAIMPFDGYNFEDAIVISEELLKRDFYTSIHIERYEIEA RDTKLGPERITRDIPHLSEAALRDLDEEGIVRIGAEVKPG DILVGRTSFKGEQEPSPEERLLRSIFGEKARDVKDTSLRV PPGEGGIVVGRLRLRRGDPGVELKPGVREVVRVFVAQKRK LQVGDKLANRHGNKGVVAKILPVEDMPHLPDGTPVDVILN PLGVPSRMNLGQILETHLGLAGYFLGQRYISPVFDGATEP EIKELLAEAFNLYFGKRQGEGFGVDKREKEVLARAEKLGL VSPGKSPEEQLKELFDLGKVVLYDGRTGEPFEGPIVVGQM FIMKLYHMVEDKMHARSTGPYSLITQQPLGGKAQFGGQRF GEMEVWALEAYGAAHTLQEMLTIKSDDIEGRNAAYQAIIK GEDVPEPSVPESFRVLVKELQALALDVQTLDEKDNPVDIF EGLA M:  KEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERD GLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVTR SIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATE LEQVLYFNKYIVLDPKGAVLDGVPVEKRQLLTDEEDARMG AEAIQELLKELDLEKLERELLEEMKHPSRARRAKARKRLE VVRAFLDSGNRPEWMILEAVPVLPPDLRPMVQVDGGRFAT SDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEA VDAVIDNGRRGSPVTNPGSERPLRSLTDILSGKQGRFRQN LLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFL LKKMEEKAFAPNVKAARRMLERQRDIKDEVWDALEEVIHG KVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFN ADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEP LAKPSRDIILGLYYITQVRKEKKGAGMAFATPEEALAAYE RGEVALNAPIVVAGRETSVGRLKFVFANPDEALLAVAHGL LDLQDVVTVRYLGRRLETSPGRILFARIVGEAVGDEKVAQ ELIQMDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYY GFTLSTTSGITIGIDDAVIPEEKQRYLEEADRKLRQIEQA YEMGFLTDRERYDQVIQLWTETTEKVTQAVFKNFEENYPF NPLYVMAQSGARGNPQQIRQLCGMRGLMQKPSGETFEVPV RSSFREGLTVLEYFISSHGARKGGADTALRTADSGYLTRK LVDVAHEIVVREADCGTTNYISVPLFQMDEVTRTLRLRKR SDIESGLYGRVLAREVEALGRRLEEGRYLSLEDVHFLIKA AEAGEVREVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSI GEAVGVVAAESIGEPGTQLTMRTPRVIELFEARRPKAKAV ISEIDGVVRIEEGEDRLSVFVESEGFSKEYKLPKDARLLV KDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVDEIQ KVYRAQGVKLHDKHIEIVVRQMLKYVEVTDPGDSRLLEGQ VLEKWDVEALNERLIAVPVAWKPLLMGVTKSALSTKSWLS AASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGT GSDFVRFTQVVDQRTLKAIEEAR N:  AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHRFKNTVLE PEERPKMRTLEGLYDDPNAVTWAMKELLTGRLFFGENLVP EDRLQKEMERLY Q:  SDPVRQYLHEIGQVPLLTLEEEIDLARKVEEGMEAIKKLS EATGLDQELIREVVRAKILGTARVEEVDGKLKSLPKELKR YLHIAREGEAARQHLIEANLRLVVSIAKKYTGRGLSFLDL IQEGNQGLIRAVEKFEYKRRFKFSTYATWWIRQAINRAIA DQARTIRIPVHMVETINKLSRTARQLQQELGREPSYEEIA EAMGPGWDAKRVEETLKIAQEPVSLETPIDFIPDENLPSP VEAAAQSLLSEELEKALSKLSEREAMVLKLRKGLIDGREH TLEEVGAYFGVTRERIRQIENKALRKLKYHESRTRKLRDF LE Description Functional site 1) chain M residue 69 type sequence E description BINDING SITE FOR RESIDUE ZN M 3003 source : AC2 2) chain M residue 70 type sequence G description BINDING SITE FOR RESIDUE ZN M 3003 source : AC2 3) chain M residue 58 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 4) chain M residue 60 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 5) chain M residue 73 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 6) chain M residue 76 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 7) chain M residue 739 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 8) chain M residue 741 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 9) chain M residue 743 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 10) chain M residue 1112 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 11) chain Q residue 413-432 type DNA_BIND sequence RQIENKALRKLKYHESRTRK description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 12) chain M residue 1194 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 13) chain M residue 1201 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 14) chain M residue 1204 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1

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