eF-site ID 1l9k-A PDB Code 1l9k Chain A click to enlarge Title dengue methyltransferase Classification TRANSFERASE Compound RNA-DIRECTED RNA POLYMERASE Source null (POLG_DEN2P) Sequence A:  ETLGEKWKSRLNALGKSEFQIYKKSGIQEVDRTLAKEGIK RGETDHHAVSRGSAKLRWFVERNLVTPEGKVVDLGCGRGG WSYYCGGLKNVREVKGLTKGGPGHEEPIPMSTYGWNLVRL QSGVDVFFIPPERCDTLLCDIGESSPNPTVEAGRTLRVLN LVENWLSNNTQFCVKVLNPYMSSVIEKMEALQRKHGGALV RNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMR HKKATYEPDVDLGSGTRNIGI Description Functional site 1) chain A residue 38 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 2) chain A residue 42 type sequence K description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 3) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 4) chain A residue 84 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 5) chain A residue 105 type sequence K description BINDING SITE FOR RESIDUE SO4 A 902 source : AC2 6) chain A residue 110 type sequence H description BINDING SITE FOR RESIDUE SO4 A 902 source : AC2 7) chain A residue 150 type sequence S description BINDING SITE FOR RESIDUE SO4 A 902 source : AC2 8) chain A residue 151 type sequence S description BINDING SITE FOR RESIDUE SO4 A 902 source : AC2 9) chain A residue 160 type sequence R description BINDING SITE FOR RESIDUE SO4 A 902 source : AC2 10) chain A residue 109 type sequence G description BINDING SITE FOR RESIDUE SO4 A 903 source : AC3 11) chain A residue 110 type sequence H description BINDING SITE FOR RESIDUE SO4 A 903 source : AC3 12) chain A residue 111 type sequence E description BINDING SITE FOR RESIDUE SO4 A 903 source : AC3 13) chain A residue 29 type sequence K description BINDING SITE FOR RESIDUE SO4 A 904 source : AC4 14) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE SO4 A 904 source : AC4 15) chain A residue 212 type sequence R description BINDING SITE FOR RESIDUE SO4 A 904 source : AC4 16) chain A residue 29 type sequence K description BINDING SITE FOR RESIDUE SO4 A 905 source : AC5 17) chain A residue 30 type sequence K description BINDING SITE FOR RESIDUE SO4 A 905 source : AC5 18) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE SO4 A 905 source : AC5 19) chain A residue 212 type sequence R description BINDING SITE FOR RESIDUE SO4 A 905 source : AC5 20) chain A residue 56 type sequence S description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 21) chain A residue 58 type sequence G description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 22) chain A residue 81 type sequence G description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 23) chain A residue 82 type sequence C description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 24) chain A residue 85 type sequence G description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 25) chain A residue 86 type sequence G description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 26) chain A residue 87 type sequence W description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 27) chain A residue 104 type sequence T description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 28) chain A residue 105 type sequence K description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 29) chain A residue 111 type sequence E description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 30) chain A residue 130 type sequence V description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 31) chain A residue 131 type sequence D description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 32) chain A residue 132 type sequence V description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 33) chain A residue 133 type sequence F description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 34) chain A residue 146 type sequence D description BINDING SITE FOR RESIDUE SAH A 887 source : AC6 35) chain A residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 181 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 217 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI2 40) chain A residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 219 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI2 47) chain A residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 14 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI3 49) chain A residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI3 50) chain A residue 212 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI3 51) chain A residue 214 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI3 52) chain A residue 18 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI3 53) chain A residue 25 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI3 54) chain A residue 29 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI3 55) chain A residue 17 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 56) chain A residue 20 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 57) chain A residue 217 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI5 58) chain A residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI5 59) chain A residue 181 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI5 60) chain A residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 61) chain A residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI7

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