eF-site ID 1l8c_18-AB
PDB Code 1l8c
Model 18
Chain A, B

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Title STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE
Classification GENE REGULATION
Compound CREB-binding protein
Source Mus musculus (Mouse) (HIF1A_HUMAN)
Sequence A:  ADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHC
RTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRH
DCPVCLPLKNASDKR
B:  SDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQG
EELLRALDQVN
Description


Functional site

1) chain A
residue 18
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 96
source : AC1

2) chain A
residue 22
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 96
source : AC1

3) chain A
residue 35
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 96
source : AC1

4) chain A
residue 40
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 96
source : AC1

5) chain A
residue 44
type
sequence K
description BINDING SITE FOR RESIDUE ZN A 96
source : AC1

6) chain A
residue 49
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 97
source : AC2

7) chain A
residue 53
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 97
source : AC2

8) chain A
residue 59
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 97
source : AC2

9) chain A
residue 64
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 97
source : AC2

10) chain A
residue 73
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 98
source : AC3

11) chain A
residue 77
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 98
source : AC3

12) chain A
residue 79
type
sequence R
description BINDING SITE FOR RESIDUE ZN A 98
source : AC3

13) chain A
residue 82
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 98
source : AC3

14) chain A
residue 85
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 98
source : AC3

15) chain B
residue 123
type MOD_RES
sequence C
description S-nitrosocysteine => ECO:0000305|PubMed:12914934
source Swiss-Prot : SWS_FT_FI1

16) chain B
residue 126
type MOD_RES
sequence N
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 77
type MOD_RES
sequence C
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 82
type MOD_RES
sequence C
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 85
type MOD_RES
sequence C
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

20) chain A
residue 22
type MOD_RES
sequence C
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 35
type MOD_RES
sequence C
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

22) chain A
residue 40
type MOD_RES
sequence C
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

23) chain A
residue 49
type MOD_RES
sequence H
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

24) chain A
residue 53
type MOD_RES
sequence C
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

25) chain A
residue 59
type MOD_RES
sequence C
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

26) chain A
residue 64
type MOD_RES
sequence C
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2

27) chain A
residue 73
type MOD_RES
sequence H
description (3S)-3-hydroxyasparagine => ECO:0000269|PubMed:12080085
source Swiss-Prot : SWS_FT_FI2


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