eF-site ID 1kzy-ABCD PDB Code 1kzy Chain A, B, C, D click to enlarge Title Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53 Classification DNA BINDING PROTEIN, PROTEIN BINDING Compound CELLULAR TUMOR ANTIGEN P53 Source Homo sapiens (Human) (TP53B_HUMAN) Sequence A:  SSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF CQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVR RCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRH SVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTI ITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENL B:  SSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMF CQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVR RCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRH SVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTI ITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENL C:  ALEEQRGPLPLNKTLFLGYAFLLTMATIPPFNKQYTESQL RAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLA SGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRIL DWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASV KQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLP VVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH D:  ALEEQRGPLPLNKTLFLGYAFLLTMATIPPFNKQYTESQL RAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLA SGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRIL DWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASV KQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLP VVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH Description (1)  CELLULAR TUMOR ANTIGEN P53, TUMOR REPRESSOR P53-BINDING PROTEIN 1 Functional site 1) chain A residue 176 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 2) chain A residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 3) chain A residue 238 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 4) chain A residue 242 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 5) chain B residue 176 type sequence C description BINDING SITE FOR RESIDUE ZN B 1 source : AC2 6) chain B residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC2 7) chain B residue 238 type sequence C description BINDING SITE FOR RESIDUE ZN B 1 source : AC2 8) chain B residue 242 type sequence C description BINDING SITE FOR RESIDUE ZN B 1 source : AC2 9) chain A residue 237-249 type prosite sequence MCNSSCMGGMNRR description P53 p53 family signature. MCNSSCMGGMNRR source prosite : PS00348 10) chain A residue 238 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 242 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 176 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 179 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 238 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 242 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI1 16) chain C residue 1778 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19176521, ECO:0000269|PubMed:21144835 source Swiss-Prot : SWS_FT_FI2 17) chain D residue 1778 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19176521, ECO:0000269|PubMed:21144835 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 120 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171 source Swiss-Prot : SWS_FT_FI3 19) chain B residue 120 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 183 type MOD_RES sequence S description Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 269 type MOD_RES sequence S description Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 source Swiss-Prot : SWS_FT_FI4 22) chain B residue 183 type MOD_RES sequence S description Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 source Swiss-Prot : SWS_FT_FI4 23) chain B residue 269 type MOD_RES sequence S description Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 284 type MOD_RES sequence T description Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 source Swiss-Prot : SWS_FT_FI5 25) chain B residue 284 type MOD_RES sequence T description Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 source Swiss-Prot : SWS_FT_FI5

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