eF-site/Summary 1kz7-B

eF-site ID	1kz7-B
PDB Code	1kz7
Chain	B

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Title	Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42
Classification	SIGNALING PROTEIN
Compound	GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS
Source	null (CDC42_HUMAN)

Sequence	B:	MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNY AVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLV CFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSAL TQKGLKNVFDEAILAALEPPEPKKSRRS

Description

Functional site


1)	chain	B
	residue	35
	type	CARBOHYD
	sequence	T
	description	(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269\|PubMed:24905543, ECO:0000269\|PubMed:7775453, ECO:0000269\|PubMed:7777059
	source	Swiss-Prot : SWS_FT_FI9

2)	chain	B
	residue	10
	type	BINDING
	sequence	G
	description
	source	Swiss-Prot : SWS_FT_FI1

3)	chain	B
	residue	115
	type	BINDING
	sequence	T
	description
	source	Swiss-Prot : SWS_FT_FI1

4)	chain	B
	residue	57
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000250
	source	Swiss-Prot : SWS_FT_FI2

5)	chain	B
	residue	32
	type	MOD_RES
	sequence	Y
	description	(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269\|PubMed:19362538, ECO:0000269\|PubMed:20622875
	source	Swiss-Prot : SWS_FT_FI3

6)	chain	B
	residue	35
	type	MOD_RES
	sequence	T
	description	(Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269\|PubMed:19039103
	source	Swiss-Prot : SWS_FT_FI4

7)	chain	B
	residue	64
	type	MOD_RES
	sequence	Y
	description	Phosphotyrosine; by SRC => ECO:0000269\|PubMed:14506284
	source	Swiss-Prot : SWS_FT_FI5

8)	chain	B
	residue	188
	type	MOD_RES
	sequence	S
	description	Cysteine methyl ester => ECO:0000269\|PubMed:10676816, ECO:0007744\|PDB:1DOA
	source	Swiss-Prot : SWS_FT_FI6

9)	chain	B
	residue	188
	type	LIPID
	sequence	S
	description	S-geranylgeranyl cysteine => ECO:0000269\|PubMed:10676816, ECO:0007744\|PDB:1DOA
	source	Swiss-Prot : SWS_FT_FI7

10)	chain	B
	residue	32
	type	CARBOHYD
	sequence	Y
	description	(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269\|PubMed:24141704
	source	Swiss-Prot : SWS_FT_FI8