eF-site ID 1kv5-A PDB Code 1kv5 Chain A click to enlarge Title Structure of Trypanosoma brucei brucei TIM with the salt-bridge-forming residue Arg191 mutated to Ser Classification ISOMERASE Compound triosephosphate isomerase, glycosomal Source null (TPIS_TRYBB) Sequence A:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAIGTGKVATPQQAQEAHALISSWVSSKIGAD VAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPE FVDIIKATQ Description Functional site 1) chain A residue 11 type sequence N description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 2) chain A residue 13 type sequence K description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 3) chain A residue 95 type sequence H description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 4) chain A residue 167 type sequence E description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 5) chain A residue 171 type sequence A description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 6) chain A residue 172 type sequence I description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 7) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 8) chain A residue 212 type sequence G description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 9) chain A residue 213 type sequence S description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 10) chain A residue 232 type sequence L description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 11) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 12) chain A residue 235 type sequence G description BINDING SITE FOR RESIDUE PGA A 1350 source : AC1 13) chain A residue 144 type sequence L description BINDING SITE FOR RESIDUE DTT A 3450 source : AC4 14) chain A residue 193 type sequence W description BINDING SITE FOR RESIDUE DTT A 3450 source : AC4 15) chain A residue 155 type sequence K description BINDING SITE FOR RESIDUE GOL A 4500 source : AC5 16) chain A residue 156 type sequence K description BINDING SITE FOR RESIDUE GOL A 4500 source : AC5 17) chain A residue 181 type sequence Q description BINDING SITE FOR RESIDUE GOL A 4503 source : AC8 18) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE GOL A 4503 source : AC8 19) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 20) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 21) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 22) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 23) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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