eF-site ID 1kq0-A PDB Code 1kq0 Chain A click to enlarge Title Human methionine aminopeptidase type II in complex with D-methionine Classification HYDROLASE Compound Methionine aminopeptidase 2 Source Homo sapiens (Human) (AMPM2_HUMAN) Sequence A:  VQTDPPSVPICDLYPNGVFPKGQECEYPEEKKALDQASEE IWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCS RKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQY DDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDAT NTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKP IRNLNGHSIGQYRIHAGKTVPIIKGGEATRMEEGEVYAIE TFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLN VINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPY PPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY Description Functional site 1) chain A residue 251 type sequence D description BINDING SITE FOR RESIDUE ZN A 479 source : AC1 2) chain A residue 262 type sequence D description BINDING SITE FOR RESIDUE ZN A 479 source : AC1 3) chain A residue 459 type sequence E description BINDING SITE FOR RESIDUE ZN A 479 source : AC1 4) chain A residue 262 type sequence D description BINDING SITE FOR RESIDUE ZN A 480 source : AC2 5) chain A residue 331 type sequence H description BINDING SITE FOR RESIDUE ZN A 480 source : AC2 6) chain A residue 364 type sequence E description BINDING SITE FOR RESIDUE ZN A 480 source : AC2 7) chain A residue 459 type sequence E description BINDING SITE FOR RESIDUE ZN A 480 source : AC2 8) chain A residue 231 type sequence H description BINDING SITE FOR RESIDUE MED A 601 source : AC3 9) chain A residue 251 type sequence D description BINDING SITE FOR RESIDUE MED A 601 source : AC3 10) chain A residue 262 type sequence D description BINDING SITE FOR RESIDUE MED A 601 source : AC3 11) chain A residue 331 type sequence H description BINDING SITE FOR RESIDUE MED A 601 source : AC3 12) chain A residue 339 type sequence H description BINDING SITE FOR RESIDUE MED A 601 source : AC3 13) chain A residue 382 type sequence H description BINDING SITE FOR RESIDUE MED A 601 source : AC3 14) chain A residue 281 type sequence K description BINDING SITE FOR RESIDUE TBU A 501 source : AC4 15) chain A residue 477 type sequence D description BINDING SITE FOR RESIDUE TBU A 501 source : AC4 16) chain A residue 246-262 type prosite sequence DICKIDFGTHISGRIID description MAP_2 Methionine aminopeptidase subfamily 2 signature. DIcKIDfGtHISGriiD source prosite : PS01202 17) chain A residue 231 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:16540317 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 339 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:16540317 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 251 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 262 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 331 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 364 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 459 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2

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