eF-site ID 1kkq-C PDB Code 1kkq Chain C click to enlarge Title Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif Classification TRANSCRIPTION Compound PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Source null (NCOR2_HUMAN) Sequence C:  TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPF VIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFA MLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE HAQLVQIIKKTESDAALHPLLQEIYRDMY Description Functional site 1) chain C residue 241 type sequence I description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 2) chain C residue 272 type sequence I description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 3) chain C residue 273 type sequence F description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 4) chain C residue 275 type sequence C description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 5) chain C residue 276 type sequence C description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 6) chain C residue 277 type sequence Q description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 7) chain C residue 279 type sequence T description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 8) chain C residue 280 type sequence S description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 9) chain C residue 314 type sequence Y description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 10) chain C residue 330 type sequence M description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 11) chain C residue 332 type sequence V description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 12) chain C residue 351 type sequence F description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 13) chain C residue 354 type sequence I description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 14) chain C residue 440 type sequence H description BINDING SITE FOR RESIDUE 471 C 777 source : AC3 15) chain C residue 280 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 16) chain C residue 314 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 17) chain C residue 464 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 18) chain C residue 433 type SITE sequence L description Essential for heterodimerization with RXRA source Swiss-Prot : SWS_FT_FI2

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