eF-site ID 1kkq-B
PDB Code 1kkq
Chain B

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Title Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif
Classification TRANSCRIPTION
Compound PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR
Source Homo sapiens (Human) (NCOR2_HUMAN)
Sequence B:  TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPF
VIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT
SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFA
MLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK
MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE
HAQLVQIIKKTESDAALHPLLQEIYRDMY
Description


Functional site

1) chain B
residue 254
type
sequence L
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

2) chain B
residue 272
type
sequence I
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

3) chain B
residue 276
type
sequence C
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

4) chain B
residue 279
type
sequence T
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

5) chain B
residue 280
type
sequence S
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

6) chain B
residue 314
type
sequence Y
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

7) chain B
residue 330
type
sequence M
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

8) chain B
residue 332
type
sequence V
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

9) chain B
residue 344
type
sequence L
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

10) chain B
residue 351
type
sequence F
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

11) chain B
residue 354
type
sequence I
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

12) chain B
residue 355
type
sequence M
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

13) chain B
residue 440
type
sequence H
description BINDING SITE FOR RESIDUE 471 B 776
source : AC2

14) chain B
residue 280
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1
source Swiss-Prot : SWS_FT_FI1

15) chain B
residue 314
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1
source Swiss-Prot : SWS_FT_FI1

16) chain B
residue 464
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1
source Swiss-Prot : SWS_FT_FI1

17) chain B
residue 433
type SITE
sequence L
description Essential for heterodimerization with RXRA
source Swiss-Prot : SWS_FT_FI2


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