eF-site ID 1kkq-B PDB Code 1kkq Chain B click to enlarge Title Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif Classification TRANSCRIPTION Compound PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Source Homo sapiens (Human) (NCOR2_HUMAN) Sequence B:  TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPF VIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFA MLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE HAQLVQIIKKTESDAALHPLLQEIYRDMY Description Functional site 1) chain B residue 254 type sequence L description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 2) chain B residue 272 type sequence I description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 3) chain B residue 276 type sequence C description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 4) chain B residue 279 type sequence T description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 5) chain B residue 280 type sequence S description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 6) chain B residue 314 type sequence Y description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 7) chain B residue 330 type sequence M description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 8) chain B residue 332 type sequence V description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 9) chain B residue 344 type sequence L description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 10) chain B residue 351 type sequence F description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 11) chain B residue 354 type sequence I description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 12) chain B residue 355 type sequence M description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 13) chain B residue 440 type sequence H description BINDING SITE FOR RESIDUE 471 B 776 source : AC2 14) chain B residue 280 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 314 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 464 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 433 type SITE sequence L description Essential for heterodimerization with RXRA source Swiss-Prot : SWS_FT_FI2

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