eF-site ID 1kkq-A PDB Code 1kkq Chain A click to enlarge Title Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif Classification TRANSCRIPTION Compound PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Source Homo sapiens (Human) (NCOR2_HUMAN) Sequence A:  TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPF VIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFA MLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE HAQLVQIIKKTESDAALHPLLQEIYRDMY Description Functional site 1) chain A residue 254 type sequence L description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 2) chain A residue 269 type sequence E description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 3) chain A residue 272 type sequence I description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 4) chain A residue 273 type sequence F description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 5) chain A residue 275 type sequence C description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 6) chain A residue 276 type sequence C description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 7) chain A residue 280 type sequence S description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 8) chain A residue 314 type sequence Y description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 9) chain A residue 332 type sequence V description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 10) chain A residue 351 type sequence F description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 11) chain A residue 354 type sequence I description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 12) chain A residue 440 type sequence H description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 13) chain A residue 444 type sequence V description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 14) chain A residue 456 type sequence L description BINDING SITE FOR RESIDUE 471 A 775 source : AC1 15) chain A residue 280 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 314 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 464 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 433 type SITE sequence L description Essential for heterodimerization with RXRA source Swiss-Prot : SWS_FT_FI2

Display surface Download Links