eF-site ID 1kkq-A
PDB Code 1kkq
Chain A

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Title Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif
Classification TRANSCRIPTION
Compound PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR
Source Homo sapiens (Human) (NCOR2_HUMAN)
Sequence A:  TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPF
VIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT
SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFA
MLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK
MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE
HAQLVQIIKKTESDAALHPLLQEIYRDMY
Description


Functional site

1) chain A
residue 254
type
sequence L
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

2) chain A
residue 269
type
sequence E
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

3) chain A
residue 272
type
sequence I
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

4) chain A
residue 273
type
sequence F
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

5) chain A
residue 275
type
sequence C
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

6) chain A
residue 276
type
sequence C
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

7) chain A
residue 280
type
sequence S
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

8) chain A
residue 314
type
sequence Y
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

9) chain A
residue 332
type
sequence V
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

10) chain A
residue 351
type
sequence F
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

11) chain A
residue 354
type
sequence I
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

12) chain A
residue 440
type
sequence H
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

13) chain A
residue 444
type
sequence V
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

14) chain A
residue 456
type
sequence L
description BINDING SITE FOR RESIDUE 471 A 775
source : AC1

15) chain A
residue 280
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 314
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 464
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 433
type SITE
sequence L
description Essential for heterodimerization with RXRA
source Swiss-Prot : SWS_FT_FI2


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