eF-site ID 1kie-AB PDB Code 1kie Chain A, B click to enlarge Title Inosine-adenosine-guanosine preferring nucleoside hydrolase from Trypanosoma vivax: Asp10Ala mutant in complex with 3-deaza-adenosine Classification HYDROLASE Compound inosine-adenosine-guanosine preferring nucleoside hydrolase Source null (Q9GPQ4_TRYVI) Sequence A:  SAKNVVLDHAGNLDDFVAMVLLASNTEKVRLIGALCTDAD CFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFP KEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQL LADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEE CVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGC PGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGT MWAMCYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEG ATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC B:  AKNVVLDHAGNLDDFVAMVLLASNTEKVRLIGALCTDADC FVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPK EWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLL ADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEEC VIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCP GLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTM WAMCYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGA TVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC Description Functional site 1) chain A residue 15 type sequence D description BINDING SITE FOR RESIDUE CA A 328 source : AC1 2) chain A residue 137 type sequence T description BINDING SITE FOR RESIDUE CA A 328 source : AC1 3) chain A residue 261 type sequence D description BINDING SITE FOR RESIDUE CA A 328 source : AC1 4) chain B residue 15 type sequence D description BINDING SITE FOR RESIDUE CA B 328 source : AC2 5) chain B residue 137 type sequence T description BINDING SITE FOR RESIDUE CA B 328 source : AC2 6) chain B residue 261 type sequence D description BINDING SITE FOR RESIDUE CA B 328 source : AC2 7) chain A residue 44 type sequence E description BINDING SITE FOR RESIDUE NI A 701 source : AC3 8) chain A residue 113 type sequence E description BINDING SITE FOR RESIDUE NI A 701 source : AC3 9) chain A residue 14 type sequence D description BINDING SITE FOR RESIDUE AD3 A 801 source : AC4 10) chain A residue 40 type sequence D description BINDING SITE FOR RESIDUE AD3 A 801 source : AC4 11) chain A residue 137 type sequence T description BINDING SITE FOR RESIDUE AD3 A 801 source : AC4 12) chain A residue 164 type sequence M description BINDING SITE FOR RESIDUE AD3 A 801 source : AC4 13) chain A residue 173 type sequence N description BINDING SITE FOR RESIDUE AD3 A 801 source : AC4 14) chain A residue 184 type sequence E description BINDING SITE FOR RESIDUE AD3 A 801 source : AC4 15) chain A residue 186 type sequence N description BINDING SITE FOR RESIDUE AD3 A 801 source : AC4 16) chain A residue 260 type sequence W description BINDING SITE FOR RESIDUE AD3 A 801 source : AC4 17) chain A residue 261 type sequence D description BINDING SITE FOR RESIDUE AD3 A 801 source : AC4 18) chain B residue 12 type sequence N description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 19) chain B residue 14 type sequence D description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 20) chain B residue 15 type sequence D description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 21) chain B residue 40 type sequence D description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 22) chain B residue 83 type sequence W description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 23) chain B residue 137 type sequence T description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 24) chain B residue 164 type sequence M description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 25) chain B residue 173 type sequence N description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 26) chain B residue 184 type sequence E description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 27) chain B residue 185 type sequence W description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 28) chain B residue 186 type sequence N description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 29) chain B residue 260 type sequence W description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5 30) chain B residue 261 type sequence D description BINDING SITE FOR RESIDUE AD3 B 802 source : AC5

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