eF-site ID 1kfx-S PDB Code 1kfx Chain S click to enlarge Title Crystal Structure of Human m-Calpain Form I Classification HYDROLASE Compound M-CALPAIN LARGE SUBUNIT Source Homo sapiens (Human) (CPNS1_HUMAN) Sequence S:  NESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHP DLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIK RWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNM IIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTG QIQVNIQEWLQLTMYS Description Functional site 1) chain S residue 852-864 type prosite sequence DSDTTGKLGFEEF description EF_HAND_1 EF-hand calcium-binding domain. DSDGSGKLGlkEF source prosite : PS00018 2) chain S residue 882-894 type prosite sequence DTDRSGTICSSEL description EF_HAND_1 EF-hand calcium-binding domain. DSDGSGKLGlkEF source prosite : PS00018 3) chain S residue 809 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:Q64537 source Swiss-Prot : SWS_FT_FI1 4) chain S residue 812 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q64537 source Swiss-Prot : SWS_FT_FI1 5) chain S residue 814 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q64537 source Swiss-Prot : SWS_FT_FI1 6) chain S residue 819 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q64537 source Swiss-Prot : SWS_FT_FI1 7) chain S residue 837 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q64537 source Swiss-Prot : SWS_FT_FI1 8) chain S residue 925 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q64537 source Swiss-Prot : SWS_FT_FI1 9) chain S residue 852 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 10) chain S residue 854 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 11) chain S residue 863 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 12) chain S residue 882 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 13) chain S residue 884 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 14) chain S residue 893 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI2 15) chain S residue 856 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI3 16) chain S residue 858 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI3 17) chain S residue 886 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI3 18) chain S residue 888 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448 source Swiss-Prot : SWS_FT_FI3 19) chain S residue 879 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4

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