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eF-site ID
|
1k9o-EI |
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PDB Code
|
1k9o |
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Chain
|
E, I |
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click to enlarge
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Title
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CRYSTAL STRUCTURE OF MICHAELIS SERPIN-TRYPSIN COMPLEX |
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Classification
|
Hydrolase/Hydrolase Inhibitor |
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Compound
|
ALASERPIN |
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Source
|
null (TRY2_RAT) |
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Sequence
|
E: |
IVGGYTCQENSVPYQVSLNSGYHFCGGSLINDQWVVSAAH
CYKSRIQVRLGEHNINVLEGNEQFVNAAKIIKHPNFDRKT
LNNDIMLIKLSSPVKLNARVATVALPSSCAPAGTQCLISG
WGNTLSSGVNEPDLLQCLDAPLLPQADCEASYPGKITDNM
VCVGFLEGGKDSCQGDAGGPVVCNGELQGIVSWGYGCALP
DNPGVYTKVCNYVDWIQDTIAAN
|
| I: |
GETDLQKILRESNDQFTAQMFSEVVKANPGQNVVLSAFSV
LPPLGQLALASVGESHDELLRALALPNDNVTKDVFADLNR
GVRAVKGVDLKMASKIYVAKGLELNDDFAAVSRDVFGSEV
QNVDFVKSVEAAGAINKWVEDQTNNRIKNLVDPDALDETT
RSVLVNAIYFKGSWKDKFVKERTMDRDFHVSKDKTIKVPT
MIGKKDVRYADVPELDAKMIEMSYEGDQASMIIILPNQVD
GITALEQKLKDPKALSRAEERLYNTEVEITLPKFKIETTT
DLKEVLSNMNIKKLFTPGAARLENLLKTKESLTVDAAIQK
AFIEVNEEGAEAAAANAFGIVPKSLILYPEVHIDRPFYFE
LKIDGIPMFNGKVIEP
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Description
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Functional site
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|
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1)
|
chain |
E |
| residue |
53-58 |
| type |
prosite |
| sequence |
VSAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
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| source |
prosite : PS00134
|
|
|
2)
|
chain |
I |
| residue |
361-371 |
| type |
prosite |
| sequence |
VHIDRPFYFEL
|
| description |
SERPIN Serpins signature. VHIDRPFYFeL
|
| source |
prosite : PS00284
|
|
|
3)
|
chain |
E |
| residue |
102 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
E |
| residue |
195 |
| type |
ACT_SITE |
| sequence |
A
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
E |
| residue |
57 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
E |
| residue |
75 |
| type |
BINDING |
| sequence |
V
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
E |
| residue |
80 |
| type |
BINDING |
| sequence |
E
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
E |
| residue |
70 |
| type |
BINDING |
| sequence |
E
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
E |
| residue |
72 |
| type |
BINDING |
| sequence |
N
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
E |
| residue |
189 |
| type |
SITE |
| sequence |
D
|
| description |
Required for specificity => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|