eF-site ID 1k8t-A PDB Code 1k8t Chain A click to enlarge Title Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) Classification TOXIN,LYASE Compound CALMODULIN-SENSITIVE ADENYLATE CYCLASE Source null (CYAA_BACAN) Sequence A:  DRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRP VNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDL SKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRI EELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDEN NEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTA DYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVT NLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYT GGDVVNHGTNEIFIINPEGEFILTKNWEMTGRFIEKNITG KDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSA EFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYL SDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQI APEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLN FTENETDNFEVFQKIIDE Description Functional site 1) chain A residue 346 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 2) chain A residue 353 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 3) chain A residue 354 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 4) chain A residue 372 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 5) chain A residue 526 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1002 source : AC2 6) chain A residue 711 type sequence I description BINDING SITE FOR RESIDUE SO4 A 1002 source : AC2 7) chain A residue 712 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1002 source : AC2 8) chain A residue 713 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1002 source : AC2 9) chain A residue 716 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1002 source : AC2 10) chain A residue 322 type sequence L description BINDING SITE FOR RESIDUE SO4 A 1003 source : AC3 11) chain A residue 507 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1003 source : AC3 12) chain A residue 552 type sequence W description BINDING SITE FOR RESIDUE SO4 A 1003 source : AC3 13) chain A residue 753 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1004 source : AC4 14) chain A residue 770 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1004 source : AC4 15) chain A residue 774 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1004 source : AC4 16) chain A residue 491 type sequence D description BINDING SITE FOR RESIDUE NI A 2001 source : AC5 17) chain A residue 493 type sequence D description BINDING SITE FOR RESIDUE NI A 2001 source : AC5 18) chain A residue 577 type sequence H description BINDING SITE FOR RESIDUE NI A 2001 source : AC5 19) chain A residue 351 type ACT_SITE sequence H description Proton acceptor => ECO:0000269|PubMed:11807546 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 493 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15719022, ECO:0007744|PDB:1XFU, ECO:0007744|PDB:1XFV, ECO:0007744|PDB:1XFW, ECO:0007744|PDB:1XFX, ECO:0007744|PDB:1XFY, ECO:0007744|PDB:1XFZ, ECO:0007744|PDB:1Y0V source Swiss-Prot : SWS_FT_FI2 21) chain A residue 577 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15719022, ECO:0007744|PDB:1XFU, ECO:0007744|PDB:1XFV, ECO:0007744|PDB:1XFW, ECO:0007744|PDB:1XFX, ECO:0007744|PDB:1XFY, ECO:0007744|PDB:1XFZ, ECO:0007744|PDB:1Y0V source Swiss-Prot : SWS_FT_FI2 22) chain A residue 491 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15719022, ECO:0007744|PDB:1XFU, ECO:0007744|PDB:1XFV, ECO:0007744|PDB:1XFW, ECO:0007744|PDB:1XFX, ECO:0007744|PDB:1XFY, ECO:0007744|PDB:1XFZ, ECO:0007744|PDB:1Y0V source Swiss-Prot : SWS_FT_FI2 23) chain A residue 548 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15719022, ECO:0007744|PDB:1XFW source Swiss-Prot : SWS_FT_FI3

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