eF-site ID 1k83-B PDB Code 1k83 Chain B click to enlarge Title Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin Classification TRANSCRIPTION/TOXIN Compound DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT Source ORGANISM_COMMON: BAKER'S YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; Sequence B:  FEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDY TLQDIICEDSTLIEISFGKIYVTKPMVNESDGVTHALYPQ EARLRNLTYSSGLFVDVKKRTYKVFIGRLPIMLRSKNCYL SEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGN IVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGR EGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHI CYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTAL GIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYM INRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLF KKLTKDIFRLAINAKTITSGLKYALATGNWGVSQVLNRYT YSSTLSHLRRTNTPIAKPRQLHNTHWGLVCPAETPEGQAC GLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQ SPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEV SMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKV RKGHIAKLMATEYQDEYTWSSLLNEGLVEYIDAEEEESIL IAMQPEDLEPDVDPAKRIRVSHHATTFTHCEIHPSMILGV AASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDT MANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYS GYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSIT ETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVI IGKTTPSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKV RVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGI VPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASP FTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIF FGPTYYQRLRHMVDDKIHARARGPGLRFGEMERDCMIAHG AASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFEC KGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSR DF Description Functional site 1) chain B residue 1163 type sequence C description BINDING SITE FOR RESIDUE ZN B3007 source : AC7 2) chain B residue 1166 type sequence C description BINDING SITE FOR RESIDUE ZN B3007 source : AC7 3) chain B residue 1182 type sequence C description BINDING SITE FOR RESIDUE ZN B3007 source : AC7 4) chain B residue 1185 type sequence C description BINDING SITE FOR RESIDUE ZN B3007 source : AC7 5) chain B residue 763 type sequence Q description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN source : BC1 6) chain B residue 765 type sequence P description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN source : BC1 7) chain B residue 837 type catalytic sequence D description 788 source MCSA : MCSA1 8) chain B residue 1185 type MOD_RES sequence C description 4-hydroxyproline => ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:363352, ECO:0000269|PubMed:4865716 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 977-989 type prosite sequence GDKFASRHGQKGT description RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT source prosite : PS01166

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