eF-site ID 1k83-A
PDB Code 1k83
Chain A

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Title Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin
Classification TRANSCRIPTION/TOXIN
Compound DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT
Source ORGANISM_COMMON: BAKER'S YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;
Sequence A:  QYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPEKIGGL
NDPRLGSIDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHV
GFIAKIKKVCECVCMHCGKLLLDEHNELMRQALAIKDSKK
RFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPT
IRKDGLKLVGSWKKEPELRVLSTEEILNIFKHISVKDFTS
LGFNEVFSRPEWMILTCLPVPPPPVRDDLTFKLADILKAN
ISLETLEHNGAPHHAIEEAESLLQFHVATYMDNDIAGQSI
RARLKGKEGRIVDFSARTVISGDPNLELDQVGVPKSIAKT
LTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRI
DLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKM
SMMAHRVKVIPYSTFRLNLSVTSPYNADFDGDEMNLHVPQ
SEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRK
LTLRDTFIELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWS
GKQILSVAIPNGIHLQRFDEGTTLLSPKDNGMLIIDGQII
FGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVV
NFWLLHNGFSTGIGDTIADGPTMREITETIAEAKKKVLDV
TKEAQANLLTAKHGMTLRESFEDNVVRFLNEARDKAGRLA
EVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGK
RIAFGFVDRTLPHFSKDDYSPESKGFVENSYLRGLTPQEF
FFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYD
NTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAF
EKRYRVDLLNTDHTLDPSLLESGSEILGDLKLQVLLDEEY
KQLVKDRKFLREVFVDGEANWPLPVNIRRIIQNAQQTFHI
DHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRD
AVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQF
LRSVVHPGEMVGVLAAQSIGEPATQMTLKKVTSGVPRLKE
ILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEHTTL
KSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSQQSPWLLR
LELDRAAMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDE
KLIIRCRVVAEEDHMLKKIENTMLENITLRGVENIERVVM
MKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVPGIDP
TRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVN
YRHMALLVDVMTTQGGLTSVTRHGFNRSNTGALMRCSFEE
TVEILFEAGASAELDDCRGVSENVILGQMAPIGTGAFDVM
IDEESL
Description


Functional site

1) chain A
residue 107
type
sequence C
description BINDING SITE FOR RESIDUE ZN A3006
source : AC6

2) chain A
residue 110
type
sequence C
description BINDING SITE FOR RESIDUE ZN A3006
source : AC6

3) chain A
residue 148
type
sequence C
description BINDING SITE FOR RESIDUE ZN A3006
source : AC6

4) chain A
residue 167
type
sequence C
description BINDING SITE FOR RESIDUE ZN A3006
source : AC6

5) chain A
residue 67
type
sequence C
description BINDING SITE FOR RESIDUE ZN A3008
source : AC8

6) chain A
residue 70
type
sequence C
description BINDING SITE FOR RESIDUE ZN A3008
source : AC8

7) chain A
residue 77
type
sequence C
description BINDING SITE FOR RESIDUE ZN A3008
source : AC8

8) chain A
residue 80
type
sequence H
description BINDING SITE FOR RESIDUE ZN A3008
source : AC8

9) chain A
residue 481
type
sequence D
description BINDING SITE FOR RESIDUE MN A3009
source : AC9

10) chain A
residue 483
type
sequence D
description BINDING SITE FOR RESIDUE MN A3009
source : AC9

11) chain A
residue 485
type
sequence D
description BINDING SITE FOR RESIDUE MN A3009
source : AC9

12) chain A
residue 719
type
sequence V
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

13) chain A
residue 723
type
sequence N
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

14) chain A
residue 726
type
sequence R
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

15) chain A
residue 756
type
sequence I
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

16) chain A
residue 759
type
sequence A
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

17) chain A
residue 760
type
sequence Q
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

18) chain A
residue 766
type
sequence G
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

19) chain A
residue 767
type
sequence Q
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

20) chain A
residue 768
type
sequence Q
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

21) chain A
residue 769
type
sequence S
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

22) chain A
residue 819
type
sequence G
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

23) chain A
residue 822
type
sequence E
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

24) chain A
residue 1081
type
sequence L
description BINDING SITE FOR CHAIN M OF ALPHA AMANITIN
source : BC1

25) chain A
residue 483
type catalytic
sequence D
description 788
source MCSA : MCSA1

26) chain A
residue 485
type catalytic
sequence D
description 788
source MCSA : MCSA1

27) chain A
residue 483
type MOD_RES
sequence D
description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306
source Swiss-Prot : SWS_FT_FI1

28) chain A
residue 485
type MOD_RES
sequence D
description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306
source Swiss-Prot : SWS_FT_FI1

29) chain A
residue 107
type MOD_RES
sequence C
description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 110
type MOD_RES
sequence C
description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306
source Swiss-Prot : SWS_FT_FI1

31) chain A
residue 148
type MOD_RES
sequence C
description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306
source Swiss-Prot : SWS_FT_FI1

32) chain A
residue 167
type MOD_RES
sequence C
description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306
source Swiss-Prot : SWS_FT_FI1

33) chain A
residue 481
type MOD_RES
sequence D
description (3R,4S)-4-hydroxyisoleucine; in form gamma-amanitin => ECO:0000269|PubMed:11805306
source Swiss-Prot : SWS_FT_FI1


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