eF-site ID 1k74-D PDB Code 1k74 Chain D click to enlarge Title The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides. Classification TRANSCRIPTION Compound Retinoic acid receptor RXR-alpha Source Homo sapiens (Human) (O43792_TOBAC) Sequence D:  PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKS PFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGC QFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEI IYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFME PKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKP IEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI VTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY Description Functional site 1) chain D residue 280 type sequence R description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 2) chain D residue 281 type sequence I description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 3) chain D residue 282 type sequence F description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 4) chain D residue 285 type sequence C description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 5) chain D residue 289 type sequence S description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 6) chain D residue 323 type sequence H description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 7) chain D residue 330 type sequence L description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 8) chain D residue 341 type sequence I description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 9) chain D residue 360 type sequence F description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 10) chain D residue 363 type sequence F description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 11) chain D residue 364 type sequence M description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 12) chain D residue 449 type sequence H description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 13) chain D residue 473 type sequence Y description BINDING SITE FOR RESIDUE 544 D 478 source : AC2 14) chain D residue 449 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 15) chain D residue 473 type MOD_RES sequence Y description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 16) chain D residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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