eF-site ID 1k6v-B PDB Code 1k6v Chain B click to enlarge Title LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE Classification HYDROLASE Compound POL polyprotein Source Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1) (POL_HV1Y2) Sequence B:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG RWKPKMIGGIGGFIKVRQYDQIPIEICGHKAIGTVLVGPT PTNVIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 69 type sequence H description BINDING SITE FOR RESIDUE ACT A 502 source : AC1 2) chain B residue 70 type sequence K description BINDING SITE FOR RESIDUE ACT A 502 source : AC1 3) chain B residue 36 type sequence M description BINDING SITE FOR RESIDUE ACT B 505 source : AC2 4) chain B residue 37 type sequence N description BINDING SITE FOR RESIDUE ACT B 505 source : AC2 5) chain B residue 14 type sequence R description BINDING SITE FOR RESIDUE ACT A 506 source : AC3 6) chain B residue 17 type sequence G description BINDING SITE FOR RESIDUE ACT A 506 source : AC3 7) chain B residue 1 type sequence P description BINDING SITE FOR RESIDUE ACT B 508 source : AC4 8) chain B residue 57 type sequence R description BINDING SITE FOR RESIDUE ACT B 508 source : AC4 9) chain B residue 69 type sequence H description BINDING SITE FOR RESIDUE ACT B 508 source : AC4 10) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 11) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 12) chain B residue 28 type sequence A description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 13) chain B residue 29 type sequence D description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 14) chain B residue 30 type sequence D description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 15) chain B residue 32 type sequence V description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 16) chain B residue 48 type sequence G description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 17) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 18) chain B residue 50 type sequence I description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 19) chain B residue 81 type sequence P description BINDING SITE FOR RESIDUE XN2 B 252 source : AC5 20) chain B residue 76 type SITE sequence L description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 76 type MOD_RES sequence L description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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