eF-site ID 1k3b-ABC PDB Code 1k3b Chain A, B, C click to enlarge Title Crystal Structure of Human Dipeptidyl Peptidase I (Cathepsin C): Exclusion Domain Added to an Endopeptidase Framework Creates the Machine for Activation of Granular Serine Proteases Classification HYDROLASE Compound dipeptydil-peptidase I exclusion domain Source (CATC_HUMAN) Sequence A:  DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKV VVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAF FKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVG B:  LPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEAR IRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKY AQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGG FYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHH TGLR C:  DPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWG ENGYFRIRRGTDECAIESIAVAATPIPKL Description (1)  dipeptydil-peptidase I exclusion domain/light chain/heavy chain (E.C.3.4.14.1) Functional site 1) chain B residue 228-239 type prosite sequence QASCGSCYSFAS description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QAsCGSCYSfAS source prosite : PS00139 2) chain C residue 381 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 379-389 type prosite sequence TNHAVLLVGYG description THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. TNHAVLLVGYG source prosite : PS00639 4) chain C residue 398-417 type prosite sequence YWIVKNSWGTGWGENGYFRI description THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWgtgWGenGYFrI source prosite : PS00640 5) chain C residue 403 type ACT_SITE sequence N description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 280 type ACT_SITE sequence Y description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 323 type ACT_SITE sequence Y description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 252 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329 source Swiss-Prot : SWS_FT_FI3

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