eF-site ID 1k32-E PDB Code 1k32 Chain E click to enlarge Title Crystal structure of the tricorn protease Classification HYDROLASE Compound tricorn protease Source null (TRI_THEAC) Sequence E:  MPNLLLNPDIHGDRIIFVCCDDLWEHDLKSGSTRKIVSNL GVINNARFFPDGRKIAIRVMRGSSLNTADLYFYNGENGEI KRITYFSGKSTGRRMFTDVAGFDPDGNLIISTDAMQPFSS MTCLYRVENDGINFVPLNLGPATHILFADGRRVIGRNTFE LPHWKGYRGGTRGKIWIEVNSGAFKKIVDMSTHVSSPVIV GHRIYFITDIDGFGQIYSTDLDGKDLRKHTSFTDYYPRHL NTDGRRILFSKGGSIYIFNPDTEKIEKIEIGDLESPEDRI ISIPSKFAEDFSPLDGDLIAFVSRGQAFIQDVSGTYVLKV PEPLRIRYVRRGGDTKVAFIHGTREGDFLGIYDYRTGKAE KFEENLGNVFAMGVDRNGKFAVVANDRFEIMTVDLETGKP TVIERSREAMITDFTISDNSRFIAYGFPLKHGETDGYVMQ AIHVYDMEGRKIFAATTENSHDYAPAFDADSKNLYYLSYR SLDPSPDRVVLNFSFEVVSKPFVIPLIPGSPNPTKLVPRS MTSEAGEYDLNDMYKRSSPINVDPGDYRMIIPLESSILIY SVPVHGEFAAYYQGAPEKGVLLKYDVKTRKVTEVKNNLTD LRLSADRKTVMVRKDDGKIYTFPLEKPEDERTVETDKRPL VSSIHEEFLQMYDEAWKLARDNYWNEAVAKEISERIYEKY RNLVPLCKTRYDLSNVIVEMQGEYRTSHSYEMGGTFTDKD PFRSGRIACDFKLDGDHYVVAKAYAGDYSNEGEKSPIFEY GIDPTGYLIEDIDGETVGAGSNIYRVLSEKAGTSARIRLS GKGGDKRDLMIDILDDDRFIRYRSWVEANRRYVHERSKGT IGYIHIPDMGMMGLNEFYRLFINESSYQGLIVDVRFNGGG FVSQLIIEKLMNKRIGYDNPRRGTLSPYPTNSVRGKIIAI TNEYAGSDGDIFSFSFKKLGLGKLIGTRTWGGVVGITPKR RLIDGTVLTQPEFAFWFRDAGFGVENYGVDPDVEIEYAPH DYLSGKDPQIDYAIDALIEELRN Description Functional site 1) chain E residue 993 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI5 2) chain E residue 746 type catalytic sequence H description 808 source MCSA : MCSA5 3) chain E residue 918 type catalytic sequence G description 808 source MCSA : MCSA5 4) chain E residue 965 type catalytic sequence S description 808 source MCSA : MCSA5 5) chain E residue 966 type catalytic sequence D description 808 source MCSA : MCSA5 6) chain E residue 746 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI1 7) chain E residue 965 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI2 8) chain E residue 1023 type ACT_SITE sequence E description Charge relay system => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI3 9) chain E residue 916 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI4 10) chain E residue 936 type SITE sequence D description Substrate specificity switch => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI6 11) chain E residue 966 type SITE sequence D description Transition state stabilizer; via amide nitrogen => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI7

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