eF-site ID 1k32-ABCDEF PDB Code 1k32 Chain A, B, C, D, E, F Title Crystal structure of the tricorn protease Classification HYDROLASE Compound tricorn protease Source null (TRI_THEAC) Sequence A:  MPNLLLNPDIHGDRIIFVCCDDLWEHDLKSGSTRKIVSNL GVINNARFFPDGRKIAIRVMRGSSLNTADLYFYNGENGEI KRITYFSGKSTGRRMFTDVAGFDPDGNLIISTDAMQPFSS MTCLYRVENDGINFVPLNLGPATHILFADGRRVIGRNTFE LPHWKGYRGGTRGKIWIEVNSGAFKKIVDMSTHVSSPVIV GHRIYFITDIDGFGQIYSTDLDGKDLRKHTSFTDYYPRHL NTDGRRILFSKGGSIYIFNPDTEKIEKIEIGDLESPEDRI ISIPSKFAEDFSPLDGDLIAFVSRGQAFIQDVSGTYVLKV PEPLRIRYVRRGGDTKVAFIHGTREGDFLGIYDYRTGKAE KFEENLGNVFAMGVDRNGKFAVVANDRFEIMTVDLETGKP TVIERSREAMITDFTISDNSRFIAYGFPLKHGETDGYVMQ AIHVYDMEGRKIFAATTENSHDYAPAFDADSKNLYYLSYR SLDPSPDRVVLNFSFEVVSKPFVIPLIPGSPNPTKLVPRS MTSEAGEYDLNDMYKRSSPINVDPGDYRMIIPLESSILIY SVPVHGEFAAYYQGAPEKGVLLKYDVKTRKVTEVKNNLTD LRLSADRKTVMVRKDDGKIYTFPLEKPEDERTVETDKRPL VSSIHEEFLQMYDEAWKLARDNYWNEAVAKEISERIYEKY RNLVPLCKTRYDLSNVIVEMQGEYRTSHSYEMGGTFTDKD PFRSGRIACDFKLDGDHYVVAKAYAGDYSNEGEKSPIFEY GIDPTGYLIEDIDGETVGAGSNIYRVLSEKAGTSARIRLS GKGGDKRDLMIDILDDDRFIRYRSWVEANRRYVHERSKGT IGYIHIPDMGMMGLNEFYRLFINESSYQGLIVDVRFNGGG FVSQLIIEKLMNKRIGYDNPRRGTLSPYPTNSVRGKIIAI TNEYAGSDGDIFSFSFKKLGLGKLIGTRTWGGVVGITPKR RLIDGTVLTQPEFAFWFRDAGFGVENYGVDPDVEIEYAPH DYLSGKDPQIDYAIDALIEELRN B:  MPNLLLNPDIHGDRIIFVCCDDLWEHDLKSGSTRKIVSNL GVINNARFFPDGRKIAIRVMRGSSLNTADLYFYNGENGEI KRITYFSGKSTGRRMFTDVAGFDPDGNLIISTDAMQPFSS MTCLYRVENDGINFVPLNLGPATHILFADGRRVIGRNTFE LPHWKGYRGGTRGKIWIEVNSGAFKKIVDMSTHVSSPVIV GHRIYFITDIDGFGQIYSTDLDGKDLRKHTSFTDYYPRHL NTDGRRILFSKGGSIYIFNPDTEKIEKIEIGDLESPEDRI ISIPSKFAEDFSPLDGDLIAFVSRGQAFIQDVSGTYVLKV PEPLRIRYVRRGGDTKVAFIHGTREGDFLGIYDYRTGKAE KFEENLGNVFAMGVDRNGKFAVVANDRFEIMTVDLETGKP TVIERSREAMITDFTISDNSRFIAYGFPLKHGETDGYVMQ AIHVYDMEGRKIFAATTENSHDYAPAFDADSKNLYYLSYR SLDPSPDRVVLNFSFEVVSKPFVIPLIPGSPNPTKLVPRS MTSEAGEYDLNDMYKRSSPINVDPGDYRMIIPLESSILIY SVPVHGEFAAYYQGAPEKGVLLKYDVKTRKVTEVKNNLTD LRLSADRKTVMVRKDDGKIYTFPLEKPEDERTVETDKRPL VSSIHEEFLQMYDEAWKLARDNYWNEAVAKEISERIYEKY RNLVPLCKTRYDLSNVIVEMQGEYRTSHSYEMGGTFTDKD PFRSGRIACDFKLDGDHYVVAKAYAGDYSNEGEKSPIFEY GIDPTGYLIEDIDGETVGAGSNIYRVLSEKAGTSARIRLS GKGGDKRDLMIDILDDDRFIRYRSWVEANRRYVHERSKGT IGYIHIPDMGMMGLNEFYRLFINESSYQGLIVDVRFNGGG FVSQLIIEKLMNKRIGYDNPRRGTLSPYPTNSVRGKIIAI TNEYAGSDGDIFSFSFKKLGLGKLIGTRTWGGVVGITPKR RLIDGTVLTQPEFAFWFRDAGFGVENYGVDPDVEIEYAPH DYLSGKDPQIDYAIDALIEELRN C:  MPNLLLNPDIHGDRIIFVCCDDLWEHDLKSGSTRKIVSNL GVINNARFFPDGRKIAIRVMRGSSLNTADLYFYNGENGEI KRITYFSGKSTGRRMFTDVAGFDPDGNLIISTDAMQPFSS MTCLYRVENDGINFVPLNLGPATHILFADGRRVIGRNTFE LPHWKGYRGGTRGKIWIEVNSGAFKKIVDMSTHVSSPVIV GHRIYFITDIDGFGQIYSTDLDGKDLRKHTSFTDYYPRHL NTDGRRILFSKGGSIYIFNPDTEKIEKIEIGDLESPEDRI ISIPSKFAEDFSPLDGDLIAFVSRGQAFIQDVSGTYVLKV PEPLRIRYVRRGGDTKVAFIHGTREGDFLGIYDYRTGKAE KFEENLGNVFAMGVDRNGKFAVVANDRFEIMTVDLETGKP TVIERSREAMITDFTISDNSRFIAYGFPLKHGETDGYVMQ AIHVYDMEGRKIFAATTENSHDYAPAFDADSKNLYYLSYR SLDPSPDRVVLNFSFEVVSKPFVIPLIPGSPNPTKLVPRS MTSEAGEYDLNDMYKRSSPINVDPGDYRMIIPLESSILIY SVPVHGEFAAYYQGAPEKGVLLKYDVKTRKVTEVKNNLTD LRLSADRKTVMVRKDDGKIYTFPLEKPEDERTVETDKRPL VSSIHEEFLQMYDEAWKLARDNYWNEAVAKEISERIYEKY RNLVPLCKTRYDLSNVIVEMQGEYRTSHSYEMGGTFTDKD PFRSGRIACDFKLDGDHYVVAKAYAGDYSNEGEKSPIFEY GIDPTGYLIEDIDGETVGAGSNIYRVLSEKAGTSARIRLS GKGGDKRDLMIDILDDDRFIRYRSWVEANRRYVHERSKGT IGYIHIPDMGMMGLNEFYRLFINESSYQGLIVDVRFNGGG FVSQLIIEKLMNKRIGYDNPRRGTLSPYPTNSVRGKIIAI TNEYAGSDGDIFSFSFKKLGLGKLIGTRTWGGVVGITPKR RLIDGTVLTQPEFAFWFRDAGFGVENYGVDPDVEIEYAPH DYLSGKDPQIDYAIDALIEELRN D:  MPNLLLNPDIHGDRIIFVCCDDLWEHDLKSGSTRKIVSNL GVINNARFFPDGRKIAIRVMRGSSLNTADLYFYNGENGEI KRITYFSGKSTGRRMFTDVAGFDPDGNLIISTDAMQPFSS MTCLYRVENDGINFVPLNLGPATHILFADGRRVIGRNTFE LPHWKGYRGGTRGKIWIEVNSGAFKKIVDMSTHVSSPVIV GHRIYFITDIDGFGQIYSTDLDGKDLRKHTSFTDYYPRHL NTDGRRILFSKGGSIYIFNPDTEKIEKIEIGDLESPEDRI ISIPSKFAEDFSPLDGDLIAFVSRGQAFIQDVSGTYVLKV PEPLRIRYVRRGGDTKVAFIHGTREGDFLGIYDYRTGKAE KFEENLGNVFAMGVDRNGKFAVVANDRFEIMTVDLETGKP TVIERSREAMITDFTISDNSRFIAYGFPLKHGETDGYVMQ AIHVYDMEGRKIFAATTENSHDYAPAFDADSKNLYYLSYR SLDPSPDRVVLNFSFEVVSKPFVIPLIPGSPNPTKLVPRS MTSEAGEYDLNDMYKRSSPINVDPGDYRMIIPLESSILIY SVPVHGEFAAYYQGAPEKGVLLKYDVKTRKVTEVKNNLTD LRLSADRKTVMVRKDDGKIYTFPLEKPEDERTVETDKRPL VSSIHEEFLQMYDEAWKLARDNYWNEAVAKEISERIYEKY RNLVPLCKTRYDLSNVIVEMQGEYRTSHSYEMGGTFTDKD PFRSGRIACDFKLDGDHYVVAKAYAGDYSNEGEKSPIFEY GIDPTGYLIEDIDGETVGAGSNIYRVLSEKAGTSARIRLS GKGGDKRDLMIDILDDDRFIRYRSWVEANRRYVHERSKGT IGYIHIPDMGMMGLNEFYRLFINESSYQGLIVDVRFNGGG FVSQLIIEKLMNKRIGYDNPRRGTLSPYPTNSVRGKIIAI TNEYAGSDGDIFSFSFKKLGLGKLIGTRTWGGVVGITPKR RLIDGTVLTQPEFAFWFRDAGFGVENYGVDPDVEIEYAPH DYLSGKDPQIDYAIDALIEELRN E:  MPNLLLNPDIHGDRIIFVCCDDLWEHDLKSGSTRKIVSNL GVINNARFFPDGRKIAIRVMRGSSLNTADLYFYNGENGEI KRITYFSGKSTGRRMFTDVAGFDPDGNLIISTDAMQPFSS MTCLYRVENDGINFVPLNLGPATHILFADGRRVIGRNTFE LPHWKGYRGGTRGKIWIEVNSGAFKKIVDMSTHVSSPVIV GHRIYFITDIDGFGQIYSTDLDGKDLRKHTSFTDYYPRHL NTDGRRILFSKGGSIYIFNPDTEKIEKIEIGDLESPEDRI ISIPSKFAEDFSPLDGDLIAFVSRGQAFIQDVSGTYVLKV PEPLRIRYVRRGGDTKVAFIHGTREGDFLGIYDYRTGKAE KFEENLGNVFAMGVDRNGKFAVVANDRFEIMTVDLETGKP TVIERSREAMITDFTISDNSRFIAYGFPLKHGETDGYVMQ AIHVYDMEGRKIFAATTENSHDYAPAFDADSKNLYYLSYR SLDPSPDRVVLNFSFEVVSKPFVIPLIPGSPNPTKLVPRS MTSEAGEYDLNDMYKRSSPINVDPGDYRMIIPLESSILIY SVPVHGEFAAYYQGAPEKGVLLKYDVKTRKVTEVKNNLTD LRLSADRKTVMVRKDDGKIYTFPLEKPEDERTVETDKRPL VSSIHEEFLQMYDEAWKLARDNYWNEAVAKEISERIYEKY RNLVPLCKTRYDLSNVIVEMQGEYRTSHSYEMGGTFTDKD PFRSGRIACDFKLDGDHYVVAKAYAGDYSNEGEKSPIFEY GIDPTGYLIEDIDGETVGAGSNIYRVLSEKAGTSARIRLS GKGGDKRDLMIDILDDDRFIRYRSWVEANRRYVHERSKGT IGYIHIPDMGMMGLNEFYRLFINESSYQGLIVDVRFNGGG FVSQLIIEKLMNKRIGYDNPRRGTLSPYPTNSVRGKIIAI TNEYAGSDGDIFSFSFKKLGLGKLIGTRTWGGVVGITPKR RLIDGTVLTQPEFAFWFRDAGFGVENYGVDPDVEIEYAPH DYLSGKDPQIDYAIDALIEELRN F:  MPNLLLNPDIHGDRIIFVCCDDLWEHDLKSGSTRKIVSNL GVINNARFFPDGRKIAIRVMRGSSLNTADLYFYNGENGEI KRITYFSGKSTGRRMFTDVAGFDPDGNLIISTDAMQPFSS MTCLYRVENDGINFVPLNLGPATHILFADGRRVIGRNTFE LPHWKGYRGGTRGKIWIEVNSGAFKKIVDMSTHVSSPVIV GHRIYFITDIDGFGQIYSTDLDGKDLRKHTSFTDYYPRHL NTDGRRILFSKGGSIYIFNPDTEKIEKIEIGDLESPEDRI ISIPSKFAEDFSPLDGDLIAFVSRGQAFIQDVSGTYVLKV PEPLRIRYVRRGGDTKVAFIHGTREGDFLGIYDYRTGKAE KFEENLGNVFAMGVDRNGKFAVVANDRFEIMTVDLETGKP TVIERSREAMITDFTISDNSRFIAYGFPLKHGETDGYVMQ AIHVYDMEGRKIFAATTENSHDYAPAFDADSKNLYYLSYR SLDPSPDRVVLNFSFEVVSKPFVIPLIPGSPNPTKLVPRS MTSEAGEYDLNDMYKRSSPINVDPGDYRMIIPLESSILIY SVPVHGEFAAYYQGAPEKGVLLKYDVKTRKVTEVKNNLTD LRLSADRKTVMVRKDDGKIYTFPLEKPEDERTVETDKRPL VSSIHEEFLQMYDEAWKLARDNYWNEAVAKEISERIYEKY RNLVPLCKTRYDLSNVIVEMQGEYRTSHSYEMGGTFTDKD PFRSGRIACDFKLDGDHYVVAKAYAGDYSNEGEKSPIFEY GIDPTGYLIEDIDGETVGAGSNIYRVLSEKAGTSARIRLS GKGGDKRDLMIDILDDDRFIRYRSWVEANRRYVHERSKGT IGYIHIPDMGMMGLNEFYRLFINESSYQGLIVDVRFNGGG FVSQLIIEKLMNKRIGYDNPRRGTLSPYPTNSVRGKIIAI TNEYAGSDGDIFSFSFKKLGLGKLIGTRTWGGVVGITPKR RLIDGTVLTQPEFAFWFRDAGFGVENYGVDPDVEIEYAPH DYLSGKDPQIDYAIDALIEELRN Description Functional site 1) chain A residue 993 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI5 2) chain B residue 993 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI5 3) chain C residue 993 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI5 4) chain D residue 993 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI5 5) chain E residue 993 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI5 6) chain F residue 993 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI5 7) chain A residue 746 type catalytic sequence H description 808 source MCSA : MCSA1 8) chain A residue 918 type catalytic sequence G description 808 source MCSA : MCSA1 9) chain A residue 965 type catalytic sequence S description 808 source MCSA : MCSA1 10) chain A residue 966 type catalytic sequence D description 808 source MCSA : MCSA1 11) chain B residue 746 type catalytic sequence H description 808 source MCSA : MCSA2 12) chain B residue 918 type catalytic sequence G description 808 source MCSA : MCSA2 13) chain B residue 965 type catalytic sequence S description 808 source MCSA : MCSA2 14) chain B residue 966 type catalytic sequence D description 808 source MCSA : MCSA2 15) chain C residue 746 type catalytic sequence H description 808 source MCSA : MCSA3 16) chain C residue 918 type catalytic sequence G description 808 source MCSA : MCSA3 17) chain C residue 965 type catalytic sequence S description 808 source MCSA : MCSA3 18) chain C residue 966 type catalytic sequence D description 808 source MCSA : MCSA3 19) chain D residue 746 type catalytic sequence H description 808 source MCSA : MCSA4 20) chain D residue 918 type catalytic sequence G description 808 source MCSA : MCSA4 21) chain D residue 965 type catalytic sequence S description 808 source MCSA : MCSA4 22) chain D residue 966 type catalytic sequence D description 808 source MCSA : MCSA4 23) chain E residue 746 type catalytic sequence H description 808 source MCSA : MCSA5 24) chain E residue 918 type catalytic sequence G description 808 source MCSA : MCSA5 25) chain E residue 965 type catalytic sequence S description 808 source MCSA : MCSA5 26) chain E residue 966 type catalytic sequence D description 808 source MCSA : MCSA5 27) chain F residue 746 type catalytic sequence H description 808 source MCSA : MCSA6 28) chain F residue 918 type catalytic sequence G description 808 source MCSA : MCSA6 29) chain F residue 965 type catalytic sequence S description 808 source MCSA : MCSA6 30) chain F residue 966 type catalytic sequence D description 808 source MCSA : MCSA6 31) chain B residue 746 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI1 32) chain C residue 746 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI1 33) chain D residue 746 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI1 34) chain E residue 746 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI1 35) chain F residue 746 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 746 type ACT_SITE sequence H description Charge relay system => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 965 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI2 38) chain C residue 965 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI2 39) chain D residue 965 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI2 40) chain E residue 965 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI2 41) chain F residue 965 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 965 type ACT_SITE sequence S description Nucleophile => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 1023 type ACT_SITE sequence E description Charge relay system => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI3 44) chain B residue 1023 type ACT_SITE sequence E description Charge relay system => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI3 45) chain C residue 1023 type ACT_SITE sequence E description Charge relay system => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI3 46) chain D residue 1023 type ACT_SITE sequence E description Charge relay system => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI3 47) chain E residue 1023 type ACT_SITE sequence E description Charge relay system => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI3 48) chain F residue 1023 type ACT_SITE sequence E description Charge relay system => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI3 49) chain A residue 916 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI4 50) chain B residue 916 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI4 51) chain C residue 916 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI4 52) chain D residue 916 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI4 53) chain E residue 916 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI4 54) chain F residue 916 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI4 55) chain A residue 936 type SITE sequence D description Substrate specificity switch => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI6 56) chain B residue 936 type SITE sequence D description Substrate specificity switch => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI6 57) chain C residue 936 type SITE sequence D description Substrate specificity switch => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI6 58) chain D residue 936 type SITE sequence D description Substrate specificity switch => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI6 59) chain E residue 936 type SITE sequence D description Substrate specificity switch => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI6 60) chain F residue 936 type SITE sequence D description Substrate specificity switch => ECO:0000269|PubMed:11719810 source Swiss-Prot : SWS_FT_FI6 61) chain A residue 966 type SITE sequence D description Transition state stabilizer; via amide nitrogen => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI7 62) chain B residue 966 type SITE sequence D description Transition state stabilizer; via amide nitrogen => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI7 63) chain C residue 966 type SITE sequence D description Transition state stabilizer; via amide nitrogen => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI7 64) chain D residue 966 type SITE sequence D description Transition state stabilizer; via amide nitrogen => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI7 65) chain E residue 966 type SITE sequence D description Transition state stabilizer; via amide nitrogen => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI7 66) chain F residue 966 type SITE sequence D description Transition state stabilizer; via amide nitrogen => ECO:0000269|PubMed:11719810, ECO:0000269|PubMed:12470958 source Swiss-Prot : SWS_FT_FI7

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