eF-site ID 1k2s-AB PDB Code 1k2s Chain A, B click to enlarge Title Structure of rat brain nNOS heme domain complexed with NG-allyl-L-arginine Classification OXIDOREDUCTASE Compound nitric-oxide synthase Source Rattus norvegicus (Rat) (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM GTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD PWNTHVW B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP VRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKE IESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR HPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW YMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKD QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ PDPWNTHVWK Description Functional site 1) chain A residue 419 type sequence I description BINDING SITE FOR RESIDUE ACT A 1860 source : AC1 2) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT A 1860 source : AC1 3) chain A residue 649 type sequence V description BINDING SITE FOR RESIDUE ACT A 1860 source : AC1 4) chain B residue 417 type sequence G description BINDING SITE FOR RESIDUE ACT B 2860 source : AC2 5) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT B 2860 source : AC2 6) chain A residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 7) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 8) chain B residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 9) chain B residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 10) chain A residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 11) chain A residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 12) chain A residue 570 type sequence M description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 13) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 14) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 15) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 16) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 17) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 18) chain A residue 704 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 19) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM A 750 source : AC4 20) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B A 1760 source : AC5 21) chain A residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B A 1760 source : AC5 22) chain A residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B A 1760 source : AC5 23) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B A 1760 source : AC5 24) chain B residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B A 1760 source : AC5 25) chain B residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B A 1760 source : AC5 26) chain B residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B A 1760 source : AC5 27) chain A residue 478 type sequence Q description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 28) chain A residue 562 type sequence Y description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 29) chain A residue 565 type sequence P description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 30) chain A residue 567 type sequence V description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 31) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 32) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 33) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 34) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 35) chain A residue 588 type sequence Y description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 36) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 37) chain A residue 597 type sequence D description BINDING SITE FOR RESIDUE ARV A 1780 source : AC6 38) chain B residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC7 39) chain B residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM B 750 source : AC7 40) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC7 41) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC7 42) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM B 750 source : AC7 43) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC7 44) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM B 750 source : AC7 45) chain A residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B B 2760 source : AC8 46) chain A residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B B 2760 source : AC8 47) chain A residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B B 2760 source : AC8 48) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B B 2760 source : AC8 49) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B B 2760 source : AC8 50) chain B residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B B 2760 source : AC8 51) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B B 2760 source : AC8 52) chain B residue 478 type sequence Q description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 53) chain B residue 562 type sequence Y description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 54) chain B residue 565 type sequence P description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 55) chain B residue 566 type sequence A description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 56) chain B residue 567 type sequence V description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 57) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 58) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 59) chain B residue 586 type sequence G description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 60) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 61) chain B residue 588 type sequence Y description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 62) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 63) chain B residue 597 type sequence D description BINDING SITE FOR RESIDUE ARV B 2780 source : AC9 64) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 65) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 66) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 67) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 68) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 69) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 70) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 71) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 72) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 73) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 74) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 75) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 76) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 77) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 78) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 79) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 80) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 81) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 82) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 83) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 84) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001

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