eF-site ID 1k2c-A
PDB Code 1k2c
Chain A

click to enlarge
Title Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound PROTEASE RETROPEPSIN
Source Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1) (POL_HV1B5)
Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADNTVIEEMSLPG
RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT
PSNIIGRNLLTQIGATLNF
Description


Functional site

1) chain A
residue 8
type
sequence R
description BINDING SITE FOR RESIDUE 0Q4 B 401
source : AC1

2) chain A
residue 23
type
sequence L
description BINDING SITE FOR RESIDUE 0Q4 B 401
source : AC1

3) chain A
residue 25
type
sequence D
description BINDING SITE FOR RESIDUE 0Q4 B 401
source : AC1

4) chain A
residue 27
type
sequence G
description BINDING SITE FOR RESIDUE 0Q4 B 401
source : AC1

5) chain A
residue 28
type
sequence A
description BINDING SITE FOR RESIDUE 0Q4 B 401
source : AC1

6) chain A
residue 29
type
sequence D
description BINDING SITE FOR RESIDUE 0Q4 B 401
source : AC1

7) chain A
residue 30
type
sequence N
description BINDING SITE FOR RESIDUE 0Q4 B 401
source : AC1

8) chain A
residue 48
type
sequence G
description BINDING SITE FOR RESIDUE 0Q4 B 401
source : AC1

9) chain A
residue 49
type
sequence G
description BINDING SITE FOR RESIDUE 0Q4 B 401
source : AC1

10) chain A
residue 25
type ACT_SITE
sequence D
description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 99
type SITE
sequence F
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 22-33
type prosite
sequence ALLDTGADNTVI
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADNTVI
source prosite : PS00141


Display surface

Download
Links