eF-site ID 1jz6-D PDB Code 1jz6 Chain D click to enlarge Title E. COLI (lacZ) BETA-GALACTOSIDASE IN COMPLEX WITH GALACTO-TETRAZOLE Classification HYDROLASE Compound Beta-Galactosidase Source null (BGAL_ECOLI) Sequence D:  RRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLR SLNGEWRFAWFPAPEAVPESWLECDLPEADTVVVPSNWQM HGYDAPIYTNVTYPITVNPPFVPTENPTGCYSLTFNVDES WLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFD LSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIFRDV SLLHKPTTQISDFHVATRFNDDFSRAVLEAEVQMCGELRD YLRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLR LNVENPKLWSAEIPNLYRAVVELHTADGTLIEAEACDVGF REVRIENGLLLLNGKPLLIRGVNRHEHHPLHGQVMDEQTM VQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDE ANIETHGMVPMNRLTDDPRWLPAMSERVTRMVQRDRNHPS VIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGAD TTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGETRP LILCEYAHAMGNSLGGFAKYWQAFRQYPRLQGGFVWDWVD QSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRT PHPALTEAKHQQQFFQFRLSGQTIEVTSEYLFRHSDNELL HWMVALDGKPLASGEVPLDVAPQGKQLIELPELPQPESAG QLWLTVRVVQPNATAWSEAGHISAWQQWRLAENLSVTLPA ASHAIPHLTTSEMDFCIELGNKRWQFNRQSGFLSQMWIGD KKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKA AGHYQAEAALLQCTADTLADAVLITTAHAWQHQGKTLFIS RKTYRIDGSGQMAITVDVEVASDTPHPARIGLNCQLAQVA ERVNWLGLGPQENYPDRLTAACFDRWDLPLSDMYTPYVFP SENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSH RHLLHAEEGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAG RYHYQLVWCQK Description Functional site 1) chain D residue 201 type sequence D description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 2) chain D residue 391 type sequence H description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 3) chain D residue 460 type sequence N description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 4) chain D residue 461 type sequence E description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 5) chain D residue 502 type sequence M description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 6) chain D residue 503 type sequence Y description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 7) chain D residue 537 type sequence E description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 8) chain D residue 540 type sequence H description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 9) chain D residue 568 type sequence W description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 10) chain D residue 601 type sequence F description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 11) chain D residue 604 type sequence N description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 12) chain D residue 999 type sequence W description BINDING SITE FOR RESIDUE GTZ D 2001 source : AC4 13) chain D residue 416 type sequence E description BINDING SITE FOR RESIDUE MG D 3001 source : CC5 14) chain D residue 418 type sequence H description BINDING SITE FOR RESIDUE MG D 3001 source : CC5 15) chain D residue 461 type sequence E description BINDING SITE FOR RESIDUE MG D 3001 source : CC5 16) chain D residue 15 type sequence D description BINDING SITE FOR RESIDUE MG D 3002 source : CC6 17) chain D residue 18 type sequence N description BINDING SITE FOR RESIDUE MG D 3002 source : CC6 18) chain D residue 21 type sequence V description BINDING SITE FOR RESIDUE MG D 3002 source : CC6 19) chain D residue 163 type sequence Q description BINDING SITE FOR RESIDUE MG D 3002 source : CC6 20) chain D residue 193 type sequence D description BINDING SITE FOR RESIDUE MG D 3002 source : CC6 21) chain D residue 201 type sequence D description BINDING SITE FOR RESIDUE NA D 3101 source : CC8 22) chain D residue 601 type sequence F description BINDING SITE FOR RESIDUE NA D 3101 source : CC8 23) chain D residue 604 type sequence N description BINDING SITE FOR RESIDUE NA D 3101 source : CC8 24) chain D residue 556 type sequence F description BINDING SITE FOR RESIDUE NA D 3102 source : CC9 25) chain D residue 559 type sequence Y description BINDING SITE FOR RESIDUE NA D 3102 source : CC9 26) chain D residue 560 type sequence P description BINDING SITE FOR RESIDUE NA D 3102 source : CC9 27) chain D residue 562 type sequence L description BINDING SITE FOR RESIDUE NA D 3102 source : CC9 28) chain D residue 931 type sequence F description BINDING SITE FOR RESIDUE NA D 3103 source : DC1 29) chain D residue 932 type sequence P description BINDING SITE FOR RESIDUE NA D 3103 source : DC1 30) chain D residue 967 type sequence L description BINDING SITE FOR RESIDUE NA D 3103 source : DC1 31) chain D residue 968 type sequence M description BINDING SITE FOR RESIDUE NA D 3103 source : DC1 32) chain D residue 970 type sequence T description BINDING SITE FOR RESIDUE NA D 3103 source : DC1 33) chain D residue 448 type sequence R description BINDING SITE FOR RESIDUE DMS A 8420 source : EC7 34) chain D residue 478 type sequence V description BINDING SITE FOR RESIDUE DMS A 8420 source : EC7 35) chain D residue 740 type sequence L description BINDING SITE FOR RESIDUE DMS C 8602 source : JC3 36) chain D residue 229 type sequence T description BINDING SITE FOR RESIDUE DMS D 8401 source : JC4 37) chain D residue 330 type sequence V description BINDING SITE FOR RESIDUE DMS D 8401 source : JC4 38) chain D residue 331 type sequence G description BINDING SITE FOR RESIDUE DMS D 8401 source : JC4 39) chain D residue 449 type sequence N description BINDING SITE FOR RESIDUE DMS D 8401 source : JC4 40) chain D residue 451 type sequence P description BINDING SITE FOR RESIDUE DMS D 8401 source : JC4 41) chain D residue 557 type sequence R description BINDING SITE FOR RESIDUE DMS D 8402 source : JC5 42) chain D residue 622 type sequence H description BINDING SITE FOR RESIDUE DMS D 8402 source : JC5 43) chain D residue 623 type sequence Q description BINDING SITE FOR RESIDUE DMS D 8402 source : JC5 44) chain D residue 628 type sequence Q description BINDING SITE FOR RESIDUE DMS D 8402 source : JC5 45) chain D residue 380 type sequence K description BINDING SITE FOR RESIDUE DMS D 8403 source : JC6 46) chain D residue 383 type sequence N description BINDING SITE FOR RESIDUE DMS D 8403 source : JC6 47) chain D residue 642 type sequence Y description BINDING SITE FOR RESIDUE DMS D 8403 source : JC6 48) chain D residue 708 type sequence W description BINDING SITE FOR RESIDUE DMS D 8403 source : JC6 49) chain D residue 32 type sequence P description BINDING SITE FOR RESIDUE DMS D 8404 source : JC7 50) chain D residue 33 type sequence F description BINDING SITE FOR RESIDUE DMS D 8404 source : JC7 51) chain D residue 36 type sequence W description BINDING SITE FOR RESIDUE DMS D 8404 source : JC7 52) chain D residue 45 type sequence D description BINDING SITE FOR RESIDUE DMS D 8404 source : JC7 53) chain D residue 271 type sequence T description BINDING SITE FOR RESIDUE DMS D 8405 source : JC8 54) chain D residue 291 type sequence L description BINDING SITE FOR RESIDUE DMS D 8405 source : JC8 55) chain D residue 292 type sequence R description BINDING SITE FOR RESIDUE DMS D 8405 source : JC8 56) chain D residue 314 type sequence E description BINDING SITE FOR RESIDUE DMS D 8406 source : JC9 57) chain D residue 316 type sequence H description BINDING SITE FOR RESIDUE DMS D 8406 source : JC9 58) chain D residue 320 type sequence G description BINDING SITE FOR RESIDUE DMS D 8406 source : JC9 59) chain D residue 508 type sequence E description BINDING SITE FOR RESIDUE DMS D 8407 source : KC1 60) chain D residue 1003 type sequence V description BINDING SITE FOR RESIDUE DMS D 8407 source : KC1 61) chain D residue 1008 type sequence Q description BINDING SITE FOR RESIDUE DMS D 8407 source : KC1 62) chain D residue 54 type sequence L description BINDING SITE FOR RESIDUE DMS D 8408 source : KC2 63) chain D residue 55 type sequence N description BINDING SITE FOR RESIDUE DMS D 8408 source : KC2 64) chain D residue 56 type sequence G description BINDING SITE FOR RESIDUE DMS D 8408 source : KC2 65) chain D residue 57 type sequence E description BINDING SITE FOR RESIDUE DMS D 8408 source : KC2 66) chain D residue 334 type sequence E description BINDING SITE FOR RESIDUE DMS D 8409 source : KC3 67) chain D residue 335 type sequence V description BINDING SITE FOR RESIDUE DMS D 8409 source : KC3 68) chain D residue 336 type sequence R description BINDING SITE FOR RESIDUE DMS D 8409 source : KC3 69) chain D residue 584 type sequence P description BINDING SITE FOR RESIDUE DMS D 8411 source : KC4 70) chain D residue 585 type sequence W description BINDING SITE FOR RESIDUE DMS D 8411 source : KC4 71) chain D residue 586 type sequence S description BINDING SITE FOR RESIDUE DMS D 8411 source : KC4 72) chain D residue 973 type sequence R description BINDING SITE FOR RESIDUE DMS D 8411 source : KC4 73) chain D residue 275 type sequence G description BINDING SITE FOR RESIDUE DMS D 8412 source : KC5 74) chain D residue 276 type sequence G description BINDING SITE FOR RESIDUE DMS D 8412 source : KC5 75) chain D residue 277 type sequence E description BINDING SITE FOR RESIDUE DMS D 8412 source : KC5 76) chain D residue 289 type sequence V description BINDING SITE FOR RESIDUE DMS D 8412 source : KC5 77) chain D residue 290 type sequence T description BINDING SITE FOR RESIDUE DMS D 8412 source : KC5 78) chain D residue 292 type sequence R description BINDING SITE FOR RESIDUE DMS D 8412 source : KC5 79) chain D residue 593 type sequence G description BINDING SITE FOR RESIDUE DMS D 8413 source : KC6 80) chain D residue 594 type sequence D description BINDING SITE FOR RESIDUE DMS D 8413 source : KC6 81) chain D residue 595 type sequence T description BINDING SITE FOR RESIDUE DMS D 8413 source : KC6 82) chain D residue 84 type sequence V description BINDING SITE FOR RESIDUE DMS D 8414 source : KC7 83) chain D residue 85 type sequence V description BINDING SITE FOR RESIDUE DMS D 8414 source : KC7 84) chain D residue 93 type sequence H description BINDING SITE FOR RESIDUE DMS D 8414 source : KC7 85) chain D residue 36 type sequence W description BINDING SITE FOR RESIDUE DMS D 8501 source : KC8 86) chain D residue 45 type sequence D description BINDING SITE FOR RESIDUE DMS D 8501 source : KC8 87) chain D residue 102 type sequence N description BINDING SITE FOR RESIDUE DMS D 8506 source : KC9 88) chain D residue 598 type sequence D description BINDING SITE FOR RESIDUE DMS D 8506 source : KC9 89) chain D residue 795 type sequence V description BINDING SITE FOR RESIDUE DMS D 8506 source : KC9 90) chain D residue 320 type sequence G description BINDING SITE FOR RESIDUE DMS D 8701 source : LC1 91) chain D residue 322 type sequence L description BINDING SITE FOR RESIDUE DMS D 8701 source : LC1 92) chain D residue 49 type sequence Q description BINDING SITE FOR RESIDUE DMS D 8703 source : LC2 93) chain D residue 130 type sequence D description BINDING SITE FOR RESIDUE DMS D 8703 source : LC2 94) chain D residue 132 type sequence S description BINDING SITE FOR RESIDUE DMS D 8703 source : LC2 95) chain D residue 133 type sequence W description BINDING SITE FOR RESIDUE DMS D 8703 source : LC2 96) chain D residue 133 type sequence W description BINDING SITE FOR RESIDUE DMS D 8705 source : LC3 97) chain D residue 134 type sequence L description BINDING SITE FOR RESIDUE DMS D 8705 source : LC3 98) chain D residue 135 type sequence Q description BINDING SITE FOR RESIDUE DMS D 8705 source : LC3 99) chain D residue 136 type sequence E description BINDING SITE FOR RESIDUE DMS D 8705 source : LC3 100) chain D residue 174 type sequence S description BINDING SITE FOR RESIDUE DMS D 8705 source : LC3 101) chain D residue 201 type catalytic sequence D description 422 source MCSA : MCSA4 102) chain D residue 357 type catalytic sequence H description 422 source MCSA : MCSA4 103) chain D residue 391 type catalytic sequence H description 422 source MCSA : MCSA4 104) chain D residue 416 type catalytic sequence E description 422 source MCSA : MCSA4 105) chain D residue 418 type catalytic sequence H description 422 source MCSA : MCSA4 106) chain D residue 461 type catalytic sequence E description 422 source MCSA : MCSA4 107) chain D residue 537 type catalytic sequence E description 422 source MCSA : MCSA4 108) chain D residue 597 type catalytic sequence N description 422 source MCSA : MCSA4 109) chain D residue 601 type catalytic sequence F description 422 source MCSA : MCSA4 110) chain D residue 604 type catalytic sequence N description 422 source MCSA : MCSA4 111) chain D residue 461 type ACT_SITE sequence E description Proton donor => ECO:0000269|PubMed:6420154 source Swiss-Prot : SWS_FT_FI1 112) chain D residue 537 type ACT_SITE sequence E description Nucleophile => ECO:0000269|PubMed:1350782 source Swiss-Prot : SWS_FT_FI2 113) chain D residue 416 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11045615 source Swiss-Prot : SWS_FT_FI4 114) chain D residue 418 type BINDING sequence H description BINDING => ECO:0000269|PubMed:11045615 source Swiss-Prot : SWS_FT_FI4 115) chain D residue 597 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11045615 source Swiss-Prot : SWS_FT_FI4 116) chain D residue 357 type SITE sequence H description Transition state stabilizer source Swiss-Prot : SWS_FT_FI5 117) chain D residue 391 type SITE sequence H description Transition state stabilizer source Swiss-Prot : SWS_FT_FI5 118) chain D residue 102 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 119) chain D residue 201 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 120) chain D residue 461 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 121) chain D residue 537 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 122) chain D residue 601 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI3 123) chain D residue 604 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 124) chain D residue 999 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI3 125) chain D residue 999 type SITE sequence W description Important for ensuring that an appropriate proportion of lactose is converted to allolactose source Swiss-Prot : SWS_FT_FI6

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