eF-site ID 1jz6-C PDB Code 1jz6 Chain C click to enlarge Title E. COLI (lacZ) BETA-GALACTOSIDASE IN COMPLEX WITH GALACTO-TETRAZOLE Classification HYDROLASE Compound Beta-Galactosidase Source Escherichia coli (strain K12) (BGAL_ECOLI) Sequence C:  RRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLR SLNGEWRFAWFPAPEAVPESWLECDLPEADTVVVPSNWQM HGYDAPIYTNVTYPITVNPPFVPTENPTGCYSLTFNVDES WLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFD LSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIFRDV SLLHKPTTQISDFHVATRFNDDFSRAVLEAEVQMCGELRD YLRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLR LNVENPKLWSAEIPNLYRAVVELHTADGTLIEAEACDVGF REVRIENGLLLLNGKPLLIRGVNRHEHHPLHGQVMDEQTM VQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDE ANIETHGMVPMNRLTDDPRWLPAMSERVTRMVQRDRNHPS VIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGAD TTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGETRP LILCEYAHAMGNSLGGFAKYWQAFRQYPRLQGGFVWDWVD QSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRT PHPALTEAKHQQQFFQFRLSGQTIEVTSEYLFRHSDNELL HWMVALDGKPLASGEVPLDVAPQGKQLIELPELPQPESAG QLWLTVRVVQPNATAWSEAGHISAWQQWRLAENLSVTLPA ASHAIPHLTTSEMDFCIELGNKRWQFNRQSGFLSQMWIGD KKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKA AGHYQAEAALLQCTADTLADAVLITTAHAWQHQGKTLFIS RKTYRIDGSGQMAITVDVEVASDTPHPARIGLNCQLAQVA ERVNWLGLGPQENYPDRLTAACFDRWDLPLSDMYTPYVFP SENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSH RHLLHAEEGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAG RYHYQLVWCQK Description Functional site 1) chain C residue 201 type sequence D description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 2) chain C residue 391 type sequence H description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 3) chain C residue 460 type sequence N description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 4) chain C residue 461 type sequence E description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 5) chain C residue 502 type sequence M description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 6) chain C residue 503 type sequence Y description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 7) chain C residue 537 type sequence E description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 8) chain C residue 540 type sequence H description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 9) chain C residue 568 type sequence W description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 10) chain C residue 604 type sequence N description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 11) chain C residue 999 type sequence W description BINDING SITE FOR RESIDUE GTZ C 2001 source : AC3 12) chain C residue 416 type sequence E description BINDING SITE FOR RESIDUE MG C 3001 source : BC9 13) chain C residue 418 type sequence H description BINDING SITE FOR RESIDUE MG C 3001 source : BC9 14) chain C residue 461 type sequence E description BINDING SITE FOR RESIDUE MG C 3001 source : BC9 15) chain C residue 15 type sequence D description BINDING SITE FOR RESIDUE MG C 3002 source : CC1 16) chain C residue 18 type sequence N description BINDING SITE FOR RESIDUE MG C 3002 source : CC1 17) chain C residue 21 type sequence V description BINDING SITE FOR RESIDUE MG C 3002 source : CC1 18) chain C residue 163 type sequence Q description BINDING SITE FOR RESIDUE MG C 3002 source : CC1 19) chain C residue 193 type sequence D description BINDING SITE FOR RESIDUE MG C 3002 source : CC1 20) chain C residue 201 type sequence D description BINDING SITE FOR RESIDUE NA C 3101 source : CC2 21) chain C residue 601 type sequence F description BINDING SITE FOR RESIDUE NA C 3101 source : CC2 22) chain C residue 604 type sequence N description BINDING SITE FOR RESIDUE NA C 3101 source : CC2 23) chain C residue 556 type sequence F description BINDING SITE FOR RESIDUE NA C 3102 source : CC3 24) chain C residue 559 type sequence Y description BINDING SITE FOR RESIDUE NA C 3102 source : CC3 25) chain C residue 560 type sequence P description BINDING SITE FOR RESIDUE NA C 3102 source : CC3 26) chain C residue 562 type sequence L description BINDING SITE FOR RESIDUE NA C 3102 source : CC3 27) chain C residue 647 type sequence S description BINDING SITE FOR RESIDUE MG C 3105 source : CC4 28) chain C residue 650 type sequence E description BINDING SITE FOR RESIDUE MG C 3105 source : CC4 29) chain C residue 670 type sequence L description BINDING SITE FOR RESIDUE MG C 3105 source : CC4 30) chain C residue 1022 type sequence Q description BINDING SITE FOR RESIDUE DMS A 8425 source : EC9 31) chain C residue 1023 type sequence K description BINDING SITE FOR RESIDUE DMS A 8425 source : EC9 32) chain C residue 229 type sequence T description BINDING SITE FOR RESIDUE DMS C 8401 source : HC2 33) chain C residue 331 type sequence G description BINDING SITE FOR RESIDUE DMS C 8401 source : HC2 34) chain C residue 448 type sequence R description BINDING SITE FOR RESIDUE DMS C 8401 source : HC2 35) chain C residue 449 type sequence N description BINDING SITE FOR RESIDUE DMS C 8401 source : HC2 36) chain C residue 451 type sequence P description BINDING SITE FOR RESIDUE DMS C 8401 source : HC2 37) chain C residue 557 type sequence R description BINDING SITE FOR RESIDUE DMS C 8402 source : HC3 38) chain C residue 622 type sequence H description BINDING SITE FOR RESIDUE DMS C 8402 source : HC3 39) chain C residue 628 type sequence Q description BINDING SITE FOR RESIDUE DMS C 8402 source : HC3 40) chain C residue 380 type sequence K description BINDING SITE FOR RESIDUE DMS C 8403 source : HC4 41) chain C residue 383 type sequence N description BINDING SITE FOR RESIDUE DMS C 8403 source : HC4 42) chain C residue 626 type sequence F description BINDING SITE FOR RESIDUE DMS C 8403 source : HC4 43) chain C residue 642 type sequence Y description BINDING SITE FOR RESIDUE DMS C 8403 source : HC4 44) chain C residue 708 type sequence W description BINDING SITE FOR RESIDUE DMS C 8403 source : HC4 45) chain C residue 32 type sequence P description BINDING SITE FOR RESIDUE DMS C 8404 source : HC5 46) chain C residue 33 type sequence F description BINDING SITE FOR RESIDUE DMS C 8404 source : HC5 47) chain C residue 36 type sequence W description BINDING SITE FOR RESIDUE DMS C 8404 source : HC5 48) chain C residue 45 type sequence D description BINDING SITE FOR RESIDUE DMS C 8404 source : HC5 49) chain C residue 310 type sequence R description BINDING SITE FOR RESIDUE DMS C 8404 source : HC5 50) chain C residue 327 type sequence A description BINDING SITE FOR RESIDUE DMS C 8404 source : HC5 51) chain C residue 271 type sequence T description BINDING SITE FOR RESIDUE DMS C 8405 source : HC6 52) chain C residue 291 type sequence L description BINDING SITE FOR RESIDUE DMS C 8405 source : HC6 53) chain C residue 292 type sequence R description BINDING SITE FOR RESIDUE DMS C 8405 source : HC6 54) chain C residue 508 type sequence E description BINDING SITE FOR RESIDUE DMS C 8407 source : HC7 55) chain C residue 1001 type sequence P description BINDING SITE FOR RESIDUE DMS C 8407 source : HC7 56) chain C residue 334 type sequence E description BINDING SITE FOR RESIDUE DMS C 8409 source : HC8 57) chain C residue 336 type sequence R description BINDING SITE FOR RESIDUE DMS C 8409 source : HC8 58) chain C residue 584 type sequence P description BINDING SITE FOR RESIDUE DMS C 8411 source : HC9 59) chain C residue 585 type sequence W description BINDING SITE FOR RESIDUE DMS C 8411 source : HC9 60) chain C residue 586 type sequence S description BINDING SITE FOR RESIDUE DMS C 8411 source : HC9 61) chain C residue 973 type sequence R description BINDING SITE FOR RESIDUE DMS C 8411 source : HC9 62) chain C residue 275 type sequence G description BINDING SITE FOR RESIDUE DMS C 8412 source : IC1 63) chain C residue 276 type sequence G description BINDING SITE FOR RESIDUE DMS C 8412 source : IC1 64) chain C residue 277 type sequence E description BINDING SITE FOR RESIDUE DMS C 8412 source : IC1 65) chain C residue 289 type sequence V description BINDING SITE FOR RESIDUE DMS C 8412 source : IC1 66) chain C residue 290 type sequence T description BINDING SITE FOR RESIDUE DMS C 8412 source : IC1 67) chain C residue 292 type sequence R description BINDING SITE FOR RESIDUE DMS C 8412 source : IC1 68) chain C residue 84 type sequence V description BINDING SITE FOR RESIDUE DMS C 8414 source : IC2 69) chain C residue 85 type sequence V description BINDING SITE FOR RESIDUE DMS C 8414 source : IC2 70) chain C residue 93 type sequence H description BINDING SITE FOR RESIDUE DMS C 8414 source : IC2 71) chain C residue 621 type sequence K description BINDING SITE FOR RESIDUE DMS C 8415 source : IC3 72) chain C residue 714 type sequence I description BINDING SITE FOR RESIDUE DMS C 8415 source : IC3 73) chain C residue 717 type sequence W description BINDING SITE FOR RESIDUE DMS C 8415 source : IC3 74) chain C residue 231 type sequence F description BINDING SITE FOR RESIDUE DMS C 8417 source : IC4 75) chain C residue 232 type sequence N description BINDING SITE FOR RESIDUE DMS C 8417 source : IC4 76) chain C residue 235 type sequence F description BINDING SITE FOR RESIDUE DMS C 8417 source : IC4 77) chain C residue 334 type sequence E description BINDING SITE FOR RESIDUE DMS C 8417 source : IC4 78) chain C residue 106 type sequence P description BINDING SITE FOR RESIDUE DMS C 8419 source : IC5 79) chain C residue 107 type sequence I description BINDING SITE FOR RESIDUE DMS C 8419 source : IC5 80) chain C residue 108 type sequence T description BINDING SITE FOR RESIDUE DMS C 8419 source : IC5 81) chain C residue 93 type sequence H description BINDING SITE FOR RESIDUE DMS C 8421 source : IC6 82) chain C residue 94 type sequence G description BINDING SITE FOR RESIDUE DMS C 8421 source : IC6 83) chain C residue 95 type sequence Y description BINDING SITE FOR RESIDUE DMS C 8421 source : IC6 84) chain C residue 926 type sequence Y description BINDING SITE FOR RESIDUE DMS C 8423 source : IC7 85) chain C residue 962 type sequence Y description BINDING SITE FOR RESIDUE DMS C 8423 source : IC7 86) chain C residue 973 type sequence R description BINDING SITE FOR RESIDUE DMS C 8423 source : IC7 87) chain C residue 647 type sequence S description BINDING SITE FOR RESIDUE DMS C 8425 source : IC8 88) chain C residue 648 type sequence D description BINDING SITE FOR RESIDUE DMS C 8425 source : IC8 89) chain C residue 649 type sequence N description BINDING SITE FOR RESIDUE DMS C 8425 source : IC8 90) chain C residue 650 type sequence E description BINDING SITE FOR RESIDUE DMS C 8425 source : IC8 91) chain C residue 45 type sequence D description BINDING SITE FOR RESIDUE DMS C 8501 source : IC9 92) chain C residue 46 type sequence R description BINDING SITE FOR RESIDUE DMS C 8501 source : IC9 93) chain C residue 47 type sequence P description BINDING SITE FOR RESIDUE DMS C 8501 source : IC9 94) chain C residue 50 type sequence Q description BINDING SITE FOR RESIDUE DMS C 8504 source : JC1 95) chain C residue 132 type sequence S description BINDING SITE FOR RESIDUE DMS C 8504 source : JC1 96) chain C residue 133 type sequence W description BINDING SITE FOR RESIDUE DMS C 8504 source : JC1 97) chain C residue 216 type sequence H description BINDING SITE FOR RESIDUE DMS C 8504 source : JC1 98) chain C residue 267 type sequence V description BINDING SITE FOR RESIDUE DMS C 8601 source : JC2 99) chain C residue 294 type sequence N description BINDING SITE FOR RESIDUE DMS C 8601 source : JC2 100) chain C residue 296 type sequence E description BINDING SITE FOR RESIDUE DMS C 8601 source : JC2 101) chain C residue 266 type sequence Q description BINDING SITE FOR RESIDUE DMS C 8602 source : JC3 102) chain C residue 267 type sequence V description BINDING SITE FOR RESIDUE DMS C 8602 source : JC3 103) chain C residue 201 type catalytic sequence D description 422 source MCSA : MCSA3 104) chain C residue 604 type catalytic sequence N description 422 source MCSA : MCSA3 105) chain C residue 357 type catalytic sequence H description 422 source MCSA : MCSA3 106) chain C residue 391 type catalytic sequence H description 422 source MCSA : MCSA3 107) chain C residue 416 type catalytic sequence E description 422 source MCSA : MCSA3 108) chain C residue 418 type catalytic sequence H description 422 source MCSA : MCSA3 109) chain C residue 461 type catalytic sequence E description 422 source MCSA : MCSA3 110) chain C residue 537 type catalytic sequence E description 422 source MCSA : MCSA3 111) chain C residue 597 type catalytic sequence N description 422 source MCSA : MCSA3 112) chain C residue 601 type catalytic sequence F description 422 source MCSA : MCSA3 113) chain C residue 461 type ACT_SITE sequence E description Proton donor => ECO:0000269|PubMed:6420154 source Swiss-Prot : SWS_FT_FI1 114) chain C residue 537 type ACT_SITE sequence E description Nucleophile => ECO:0000269|PubMed:1350782 source Swiss-Prot : SWS_FT_FI2 115) chain C residue 102 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 116) chain C residue 201 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 117) chain C residue 461 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 118) chain C residue 537 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 119) chain C residue 601 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI3 120) chain C residue 604 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 121) chain C residue 999 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI3 122) chain C residue 416 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11045615 source Swiss-Prot : SWS_FT_FI4 123) chain C residue 418 type BINDING sequence H description BINDING => ECO:0000269|PubMed:11045615 source Swiss-Prot : SWS_FT_FI4 124) chain C residue 597 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11045615 source Swiss-Prot : SWS_FT_FI4 125) chain C residue 357 type SITE sequence H description Transition state stabilizer source Swiss-Prot : SWS_FT_FI5 126) chain C residue 391 type SITE sequence H description Transition state stabilizer source Swiss-Prot : SWS_FT_FI5 127) chain C residue 999 type SITE sequence W description Important for ensuring that an appropriate proportion of lactose is converted to allolactose source Swiss-Prot : SWS_FT_FI6

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