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eF-site ID
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1jwj-B |
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PDB Code
|
1jwj |
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Chain
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B |
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click to enlarge
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Title
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Murine Inducible Nitric Oxide Synthase Oxygenase Dimer (Delta 65) with W457F Mutation at Tetrahydrobiopterin Binding Site |
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Classification
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OXIDOREDUCTASE |
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Compound
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Nitric Oxide Synthase |
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Source
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(NOS2_MOUSE) |
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Sequence
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B: |
QYVRIKNWGSGEILHDTLHHKATLGSIMNPKSLTRGPRDK
PTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKE
IETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVF
DARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSD
GKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCID
LGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTME
HPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGW
YMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKD
RAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYR
ARGGCPADWIFLVPPVSGSITPVFHQEMLNYVLSPFYYYQ
IEPWKTHIWQN
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Description
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Functional site
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1)
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chain |
B |
| residue |
257 |
| type |
BINDING |
| sequence |
Q
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| description |
BINDING => ECO:0000250|UniProtKB:P29474
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| source |
Swiss-Prot : SWS_FT_FI4
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2)
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chain |
B |
| residue |
366 |
| type |
BINDING |
| sequence |
W
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| description |
BINDING => ECO:0000250|UniProtKB:P29474
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| source |
Swiss-Prot : SWS_FT_FI4
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3)
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chain |
B |
| residue |
367 |
| type |
BINDING |
| sequence |
Y
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| description |
BINDING => ECO:0000250|UniProtKB:P29474
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| source |
Swiss-Prot : SWS_FT_FI4
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|
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4)
|
chain |
B |
| residue |
371 |
| type |
BINDING |
| sequence |
E
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| description |
BINDING => ECO:0000250|UniProtKB:P29474
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| source |
Swiss-Prot : SWS_FT_FI4
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|
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5)
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chain |
B |
| residue |
375 |
| type |
BINDING |
| sequence |
R
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| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:3NOD
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| source |
Swiss-Prot : SWS_FT_FI5
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6)
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chain |
B |
| residue |
456 |
| type |
BINDING |
| sequence |
I
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| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N
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| source |
Swiss-Prot : SWS_FT_FI6
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7)
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chain |
B |
| residue |
457 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
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| source |
Swiss-Prot : SWS_FT_FI7
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8)
|
chain |
B |
| residue |
470 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
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| source |
Swiss-Prot : SWS_FT_FI8
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9)
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chain |
B |
| residue |
485 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
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| source |
Swiss-Prot : SWS_FT_FI9
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10)
|
chain |
B |
| residue |
112 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
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| source |
Swiss-Prot : SWS_FT_FI2
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11)
|
chain |
B |
| residue |
194 |
| type |
BINDING |
| sequence |
C
|
| description |
axial binding residue => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9334294, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOC, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1NOS, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:2NOS, ECO:0007744|PDB:3NOD
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| source |
Swiss-Prot : SWS_FT_FI3
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