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|
eF-site ID
|
1jwj-AB |
|
PDB Code
|
1jwj |
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Chain
|
A, B |
|
click to enlarge
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Title
|
Murine Inducible Nitric Oxide Synthase Oxygenase Dimer (Delta 65) with W457F Mutation at Tetrahydrobiopterin Binding Site |
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Classification
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OXIDOREDUCTASE |
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Compound
|
Nitric Oxide Synthase |
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Source
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(NOS2_MOUSE) |
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Sequence
|
A: |
QYVRIKNWGSGEILHDTLHHKATCLGSIMNPKSLTRGPRD
KPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTK
EIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQV
FDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRS
DGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCI
DLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTM
EHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNG
WYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWK
DRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEY
RARGGCPADWIFLVPPVSGSITPVFHQEMLNYVLSPFYYY
QIEPWKTHIWQN
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| B: |
QYVRIKNWGSGEILHDTLHHKATLGSIMNPKSLTRGPRDK
PTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKE
IETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVF
DARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSD
GKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCID
LGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTME
HPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGW
YMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKD
RAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYR
ARGGCPADWIFLVPPVSGSITPVFHQEMLNYVLSPFYYYQ
IEPWKTHIWQN
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
193-200 |
| type |
prosite |
| sequence |
RCIGRIQW
|
| description |
NOS Nitric oxide synthase (NOS) signature. RCIGRIqW
|
| source |
prosite : PS60001
|
|
|
2)
|
chain |
A |
| residue |
257 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000250|UniProtKB:P29474
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
3)
|
chain |
A |
| residue |
366 |
| type |
BINDING |
| sequence |
W
|
| description |
BINDING => ECO:0000250|UniProtKB:P29474
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
4)
|
chain |
A |
| residue |
367 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000250|UniProtKB:P29474
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
5)
|
chain |
A |
| residue |
371 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250|UniProtKB:P29474
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
6)
|
chain |
B |
| residue |
257 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000250|UniProtKB:P29474
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
7)
|
chain |
B |
| residue |
366 |
| type |
BINDING |
| sequence |
W
|
| description |
BINDING => ECO:0000250|UniProtKB:P29474
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
8)
|
chain |
B |
| residue |
367 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000250|UniProtKB:P29474
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
9)
|
chain |
B |
| residue |
371 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250|UniProtKB:P29474
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
10)
|
chain |
A |
| residue |
375 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
11)
|
chain |
B |
| residue |
375 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
12)
|
chain |
A |
| residue |
456 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
13)
|
chain |
B |
| residue |
456 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
14)
|
chain |
A |
| residue |
457 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI7
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|
|
15)
|
chain |
B |
| residue |
457 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI7
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|
|
16)
|
chain |
A |
| residue |
470 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI8
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|
|
17)
|
chain |
B |
| residue |
470 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
18)
|
chain |
A |
| residue |
485 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
19)
|
chain |
B |
| residue |
485 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
20)
|
chain |
A |
| residue |
109 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1N2N
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
21)
|
chain |
A |
| residue |
194 |
| type |
BINDING |
| sequence |
C
|
| description |
axial binding residue => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9334294, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOC, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1NOS, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:2NOS, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
22)
|
chain |
B |
| residue |
194 |
| type |
BINDING |
| sequence |
C
|
| description |
axial binding residue => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9334294, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOC, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1NOS, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:2NOS, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
23)
|
chain |
A |
| residue |
112 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
24)
|
chain |
B |
| residue |
112 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|