eF-site ID 1jwh-C PDB Code 1jwh Chain C click to enlarge Title Crystal Structure of Human Protein Kinase CK2 Holoenzyme Classification TRANSFERASE Compound Casein kinase II, alpha chain Source Homo sapiens (Human) (CSK2B_HUMAN) Sequence C:  EVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPH YRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHA RYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLS DIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPH MLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAAS Description Functional site 1) chain C residue 147 type sequence K description BINDING SITE FOR RESIDUE PO4 C 353 source : AC4 2) chain C residue 148 type sequence S description BINDING SITE FOR RESIDUE PO4 C 353 source : AC4 3) chain C residue 150 type sequence R description BINDING SITE FOR RESIDUE PO4 C 353 source : AC4 4) chain C residue 57 type sequence E description BINDING SITE FOR RESIDUE PO4 D 355 source : AC6 5) chain C residue 109 type sequence C description BINDING SITE FOR RESIDUE ZN C 357 source : AC8 6) chain C residue 114 type sequence C description BINDING SITE FOR RESIDUE ZN C 357 source : AC8 7) chain C residue 137 type sequence C description BINDING SITE FOR RESIDUE ZN C 357 source : AC8 8) chain C residue 140 type sequence C description BINDING SITE FOR RESIDUE ZN C 357 source : AC8 9) chain C residue 144 type sequence Y description BINDING SITE FOR RESIDUE ZN C 357 source : AC8 10) chain C residue 109-140 type prosite sequence CPRVYCENQPMLPIGLSDIPGEAMVKLYCPKC description CK2_BETA Casein kinase II regulatory subunit signature. CPrVyCenqpmLPIGlsdipgeamVKlyCPkC source prosite : PS01101 11) chain C residue 109 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 12) chain C residue 114 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 13) chain C residue 137 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 14) chain C residue 140 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 15) chain C residue 8 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976 source Swiss-Prot : SWS_FT_FI3 16) chain C residue 69 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976 source Swiss-Prot : SWS_FT_FI3 17) chain C residue 37 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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