eF-site ID 1jwh-A PDB Code 1jwh Chain A click to enlarge Title Crystal Structure of Human Protein Kinase CK2 Holoenzyme Classification TRANSFERASE Compound Casein kinase II, alpha chain Source Homo sapiens (Human) (CSK2B_HUMAN) Sequence A:  SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQL VRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKRE IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHN VMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRW ERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH PYFYTVVKDQARMGSS Description Functional site 1) chain A residue 234 type sequence H description BINDING SITE FOR RESIDUE PO4 A 350 source : AC1 2) chain A residue 244 type sequence R description BINDING SITE FOR RESIDUE PO4 A 350 source : AC1 3) chain A residue 51 type sequence S description BINDING SITE FOR RESIDUE ANP A 340 source : BC1 4) chain A residue 66 type sequence V description BINDING SITE FOR RESIDUE ANP A 340 source : BC1 5) chain A residue 68 type sequence K description BINDING SITE FOR RESIDUE ANP A 340 source : BC1 6) chain A residue 114 type sequence E description BINDING SITE FOR RESIDUE ANP A 340 source : BC1 7) chain A residue 116 type sequence V description BINDING SITE FOR RESIDUE ANP A 340 source : BC1 8) chain A residue 160 type sequence H description BINDING SITE FOR RESIDUE ANP A 340 source : BC1 9) chain A residue 163 type sequence M description BINDING SITE FOR RESIDUE ANP A 340 source : BC1 10) chain A residue 175 type sequence D description BINDING SITE FOR RESIDUE ANP A 340 source : BC1 11) chain A residue 45-68 type prosite sequence LGRGKYSEVFEAINITNNEKVVVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK source prosite : PS00107 12) chain A residue 152-164 type prosite sequence IMHRDVKPHNVMI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI source prosite : PS00108

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