eF-site ID 1jvs-B PDB Code 1jvs Chain B click to enlarge Title Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs Classification OXIDOREDUCTASE Compound 1-deoxy-D-xylulose 5-phosphate reductoisomerase Source (DXR_ECOLI) Sequence B:  GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVT RXVEQCLEFSPRYAVXDDEASAKLLKTXLQQQGSRTEVLS GQQAACDXAALEDVDQVXAAIVGAAGLLPTLAAIRAGKTI LLANKESLVTCGRLFXDAVKQSKAQLLPVDSEHNAIFQSL PQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLAT XTPDQACRHPNWSXGRKISVDSATXXNKGLEYIEARWLFN ASASQXEVLIHPQSVIHSXVRYQDGSVLAQLGEPDXRTPI AHTXAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKL AXEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN LSVLEKXDXREPQCVDDVLSVDANAREVARKEVXRLAS Description (1)  1-deoxy-D-xylulose 5-phosphate reductoisomerase(1.1.1.267)/ NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Functional site 1) chain B residue 184 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 2) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 3) chain B residue 208 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 4) chain B residue 221 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 5) chain B residue 226 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 6) chain B residue 227 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 7) chain B residue 7 type sequence G description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 8) chain B residue 9 type sequence T description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 9) chain B residue 10 type sequence G description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 10) chain B residue 11 type sequence S description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 11) chain B residue 12 type sequence I description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 12) chain B residue 34 type sequence A description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 13) chain B residue 35 type sequence G description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 14) chain B residue 36 type sequence K description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 15) chain B residue 37 type sequence N description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 16) chain B residue 56 type sequence D description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 17) chain B residue 99 type sequence A description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 18) chain B residue 101 type sequence V description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 19) chain B residue 104 type sequence A description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 20) chain B residue 122 type sequence A description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 21) chain B residue 123 type sequence N description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 22) chain B residue 124 type sequence K description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 23) chain B residue 149 type sequence D description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 24) chain B residue 9 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 25) chain B residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 26) chain B residue 11 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 27) chain B residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 28) chain B residue 35 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 29) chain B residue 36 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 30) chain B residue 37 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 31) chain B residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 32) chain B residue 124 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 33) chain B residue 125 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 34) chain B residue 150 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 35) chain B residue 185 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 36) chain B residue 208 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 37) chain B residue 214 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 38) chain B residue 221 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 39) chain B residue 226 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 40) chain B residue 227 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 41) chain B residue 149 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 42) chain B residue 151 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 43) chain B residue 230 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2

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