eF-site ID 1jvs-AB PDB Code 1jvs Chain A, B click to enlarge Title Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs Classification OXIDOREDUCTASE Compound 1-deoxy-D-xylulose 5-phosphate reductoisomerase Source (DXR_ECOLI) Sequence A:  GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVT RXVEQCLEFSPRYAVXDDEASAKLLKTXLQQQGSRTEVLS GQQAACDXAALEDVDQVXAAIVGAAGLLPTLAAIRAGKTI LLANKESLVTCGRLFXDAVKQSKAQLLPVDSEHNAIFQSL PQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLAT XTPDQACRHPNWSXGRKISVDSATXXNKGLEYIEARWLFN ASASQXEVLIHPQSVIHSXVRYQDGSVLAQLGEPDXRTPI AHTXAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKL AXEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN LSVLEKXDXREPQCVDDVLSVDANAREVARKEVXRLASSA B:  GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVT RXVEQCLEFSPRYAVXDDEASAKLLKTXLQQQGSRTEVLS GQQAACDXAALEDVDQVXAAIVGAAGLLPTLAAIRAGKTI LLANKESLVTCGRLFXDAVKQSKAQLLPVDSEHNAIFQSL PQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLAT XTPDQACRHPNWSXGRKISVDSATXXNKGLEYIEARWLFN ASASQXEVLIHPQSVIHSXVRYQDGSVLAQLGEPDXRTPI AHTXAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKL AXEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN LSVLEKXDXREPQCVDDVLSVDANAREVARKEVXRLAS Description (1)  1-deoxy-D-xylulose 5-phosphate reductoisomerase(1.1.1.267)/ NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Functional site 1) chain A residue 184 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 2) chain A residue 185 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 3) chain A residue 208 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 4) chain A residue 221 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 5) chain A residue 226 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 6) chain A residue 227 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 7) chain B residue 184 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 8) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 9) chain B residue 208 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 10) chain B residue 221 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 11) chain B residue 226 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 12) chain B residue 227 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 13) chain A residue 7 type sequence G description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 14) chain A residue 9 type sequence T description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 15) chain A residue 10 type sequence G description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 16) chain A residue 11 type sequence S description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 17) chain A residue 12 type sequence I description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 18) chain A residue 34 type sequence A description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 19) chain A residue 35 type sequence G description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 20) chain A residue 36 type sequence K description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 21) chain A residue 37 type sequence N description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 22) chain A residue 56 type sequence D description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 23) chain A residue 99 type sequence A description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 24) chain A residue 100 type sequence I description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 25) chain A residue 101 type sequence V description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 26) chain A residue 104 type sequence A description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 27) chain A residue 122 type sequence A description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 28) chain A residue 123 type sequence N description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 29) chain A residue 149 type sequence D description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 30) chain A residue 275 type sequence X description BINDING SITE FOR RESIDUE NDP A 2001 source : AC3 31) chain B residue 7 type sequence G description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 32) chain B residue 9 type sequence T description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 33) chain B residue 10 type sequence G description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 34) chain B residue 11 type sequence S description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 35) chain B residue 12 type sequence I description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 36) chain B residue 34 type sequence A description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 37) chain B residue 35 type sequence G description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 38) chain B residue 36 type sequence K description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 39) chain B residue 37 type sequence N description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 40) chain B residue 56 type sequence D description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 41) chain B residue 99 type sequence A description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 42) chain B residue 101 type sequence V description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 43) chain B residue 104 type sequence A description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 44) chain B residue 122 type sequence A description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 45) chain B residue 123 type sequence N description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 46) chain B residue 124 type sequence K description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 47) chain B residue 149 type sequence D description BINDING SITE FOR RESIDUE NDP B 2002 source : AC4 48) chain A residue 9 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 49) chain A residue 125 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 50) chain A residue 150 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 51) chain A residue 185 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 52) chain A residue 208 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 53) chain A residue 214 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 54) chain A residue 221 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 55) chain A residue 226 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 56) chain A residue 227 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 57) chain B residue 9 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 58) chain B residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 59) chain A residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 60) chain B residue 11 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 61) chain B residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 62) chain B residue 35 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 63) chain B residue 36 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 64) chain B residue 37 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 65) chain B residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 66) chain B residue 124 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 67) chain B residue 125 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 68) chain B residue 150 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 69) chain B residue 185 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 70) chain A residue 11 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 71) chain B residue 208 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 72) chain B residue 214 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 73) chain B residue 221 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 74) chain B residue 226 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 75) chain B residue 227 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 76) chain A residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 77) chain A residue 35 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 78) chain A residue 36 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 79) chain A residue 37 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 80) chain A residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 81) chain A residue 124 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 82) chain A residue 149 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 83) chain A residue 151 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 84) chain A residue 230 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 85) chain B residue 149 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 86) chain B residue 151 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 87) chain B residue 230 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2

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