|
|
eF-site ID
|
1ju5-ABC |
|
PDB Code
|
1ju5 |
|
Chain
|
A, B, C |
|
click to enlarge
|
|
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Title
|
Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy |
|
Classification
|
PROTEIN BINDING/TRANSFERASE |
|
Compound
|
Crk |
|
Source
|
Homo sapiens (Human) (ABL1_HUMAN) |
|
|
Sequence
|
A: |
SWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSV
SENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGD
QEFDSLPALLEFYKIHYLDTTTLIEPVSR
|
| B: |
EPGPXAQPSVNTK
|
| C: |
DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCE
AQTKNGQGWVPSNYITPVNS
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
C |
| residue |
70 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16912036, ECO:0000269|PubMed:18775435
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
C |
| residue |
115 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0000269|PubMed:16912036
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
74 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
A |
| residue |
83 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
5)
|
chain |
A |
| residue |
108 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|