|
|
eF-site ID
|
1jsu-ABC |
|
PDB Code
|
1jsu |
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Chain
|
A, B, C |
|
click to enlarge
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Title
|
P27(KIP1)/CYCLIN A/CDK2 COMPLEX |
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Classification
|
COMPLEX (TRANSFERASE/CYCLIN/INHIBITOR) |
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Compound
|
CYCLIN-DEPENDENT KINASE-2 |
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Source
|
Homo sapiens (Human) (CDN1B_HUMAN) |
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Sequence
|
A: |
GTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREI
SLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMD
ASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQN
LLINTEGAIKLADFGLARAFGVPVRTYXHEVVTLWYRAPE
ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQL
FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVV
PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP
VPHLRL
|
| B: |
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAIL
VDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ
LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM
EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAM
FLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK
NSKYHGVSLLNPPETLNL
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| C: |
KPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDF
QNHKPLEGKYEWQEVEKGSLPEFYYRPPR
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Description
|
(1) |
CYCLIN-DEPENDENT KINASE-2, CYCLIN A, P27
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Functional site
|
|
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1)
|
chain |
A |
| residue |
214 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE SO4 A 299
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
217 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE SO4 A 299
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
278 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE SO4 A 299
|
| source |
: AC1
|
|
|
4)
|
chain |
C |
| residue |
74 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by SRC => ECO:0000269|PubMed:17254967
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
C |
| residue |
88 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by ABL, LYN, SRC and JAK2 => ECO:0000269|PubMed:16195327, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:17254967, ECO:0000269|PubMed:21423214
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
33 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphotyrosine; by ABL, LYN, SRC and JAK2 => ECO:0000269|PubMed:16195327, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:17254967, ECO:0000269|PubMed:21423214
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
A |
| residue |
81 |
| type |
MOD_RES |
| sequence |
E
|
| description |
Phosphotyrosine; by ABL, LYN, SRC and JAK2 => ECO:0000269|PubMed:16195327, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:17254967, ECO:0000269|PubMed:21423214
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
86 |
| type |
MOD_RES |
| sequence |
D
|
| description |
Phosphotyrosine; by ABL, LYN, SRC and JAK2 => ECO:0000269|PubMed:16195327, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:17254967, ECO:0000269|PubMed:21423214
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
129 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphotyrosine; by ABL, LYN, SRC and JAK2 => ECO:0000269|PubMed:16195327, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:17254967, ECO:0000269|PubMed:21423214
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
C |
| residue |
89 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0000269|PubMed:16195327
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
11)
|
chain |
A |
| residue |
145 |
| type |
MOD_RES |
| sequence |
D
|
| description |
Phosphotyrosine => ECO:0000269|PubMed:16195327
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
12)
|
chain |
B |
| residue |
211-242 |
| type |
prosite |
| sequence |
RAILVDWLVEVGEEYKLQNETLHLAVNYIDRF
|
| description |
CYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF
|
| source |
prosite : PS00292
|
|
|
13)
|
chain |
A |
| residue |
123-135 |
| type |
prosite |
| sequence |
VLHRDLKPQNLLI
|
| description |
PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
|
| source |
prosite : PS00108
|
|
|
14)
|
chain |
A |
| residue |
160 |
| type |
MOD_RES |
| sequence |
X
|
| description |
Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
15)
|
chain |
A |
| residue |
88 |
| type |
SITE |
| sequence |
K
|
| description |
CDK7 binding
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
16)
|
chain |
A |
| residue |
166 |
| type |
SITE |
| sequence |
L
|
| description |
CDK7 binding
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
17)
|
chain |
A |
| residue |
19 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0007744|PubMed:19369195
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
18)
|
chain |
A |
| residue |
14 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
19)
|
chain |
A |
| residue |
15 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by WEE1 => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507, ECO:0007744|PubMed:19690332
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
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