eF-site ID 1jrc-AB PDB Code 1jrc Chain A, B click to enlarge Title The N67A mutant of Lactococcus lactis dihydroorotate dehydrogenase A Classification OXIDOREDUCTASE Compound dihydroorotate dehydrogenase A Source Lactococcus lactis subsp. cremoris (Streptococcus cremoris) (PYRDA_LACLC) Sequence A:  MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAY ITKSSTLEKREGNPLPRYVDLELGSIASMGLPNLGFDYYL DYVLKNQKENAQEGPIFFSIAGMSAAENIAMLKKIQESDF SGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKP LGVKLPPYFDLVHFDIMAEILNQFPLTYVNSVNSIGNGLF IDPEAESVVIKPKDGFGGIGGAYIKPTALANVRAFYTRLK PEIQIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPA IFDRIIKELEEIMNQKGYQSIADFHGKLKSL B:  MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAY ITKSSTLEKREGNPLPRYVDLELGSIASMGLPNLGFDYYL DYVLKNQKENAQEGPIFFSIAGMSAAENIAMLKKIQESDF SGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKP LGVKLPPYFDLVHFDIMAEILNQFPLTYVNSVNSIGNGLF IDPEAESVVIKPKDGFGGIGGAYIKPTALANVRAFYTRLK PEIQIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPA IFDRIIKELEEIMNQKGYQSIADFHGKLKSL Description Functional site 1) chain A residue 18 type sequence A description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 2) chain A residue 19 type sequence S description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 3) chain A residue 20 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 4) chain A residue 43 type sequence K description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 5) chain A residue 44 type sequence S description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 6) chain A residue 127 type sequence N description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 7) chain A residue 164 type sequence K description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 8) chain A residue 192 type sequence V description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 9) chain A residue 193 type sequence N description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 10) chain A residue 221 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 11) chain A residue 248 type sequence T description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 12) chain A residue 249 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 13) chain A residue 250 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 14) chain A residue 271 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 15) chain A residue 272 type sequence T description BINDING SITE FOR RESIDUE FMN A 1312 source : AC1 16) chain A residue 43 type sequence K description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 17) chain A residue 69 type sequence M description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 18) chain A residue 70 type sequence G description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 19) chain A residue 71 type sequence L description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 20) chain A residue 127 type sequence N description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 21) chain A residue 130 type sequence C description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 22) chain A residue 131 type sequence P description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 23) chain A residue 132 type sequence N description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 24) chain A residue 193 type sequence N description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 25) chain A residue 194 type sequence S description BINDING SITE FOR RESIDUE ORO A 1313 source : AC2 26) chain B residue 18 type sequence A description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 27) chain B residue 19 type sequence S description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 28) chain B residue 20 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 29) chain B residue 43 type sequence K description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 30) chain B residue 44 type sequence S description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 31) chain B residue 127 type sequence N description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 32) chain B residue 164 type sequence K description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 33) chain B residue 192 type sequence V description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 34) chain B residue 193 type sequence N description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 35) chain B residue 221 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 36) chain B residue 248 type sequence T description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 37) chain B residue 249 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 38) chain B residue 250 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 39) chain B residue 271 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 40) chain B residue 272 type sequence T description BINDING SITE FOR RESIDUE FMN B 2312 source : AC3 41) chain B residue 43 type sequence K description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 42) chain B residue 69 type sequence M description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 43) chain B residue 70 type sequence G description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 44) chain B residue 71 type sequence L description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 45) chain B residue 127 type sequence N description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 46) chain B residue 130 type sequence C description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 47) chain B residue 131 type sequence P description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 48) chain B residue 132 type sequence N description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 49) chain B residue 193 type sequence N description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 50) chain B residue 194 type sequence S description BINDING SITE FOR RESIDUE ORO B 2313 source : AC4 51) chain A residue 43 type catalytic sequence K description 892 source MCSA : MCSA1 52) chain A residue 130 type catalytic sequence C description 892 source MCSA : MCSA1 53) chain B residue 43 type catalytic sequence K description 892 source MCSA : MCSA2 54) chain B residue 130 type catalytic sequence C description 892 source MCSA : MCSA2 55) chain A residue 130 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 56) chain B residue 130 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 57) chain A residue 19 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 221 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 59) chain B residue 249 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 60) chain B residue 271 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 61) chain A residue 164 type BINDING sequence K description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 62) chain A residue 192 type BINDING sequence V description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 63) chain A residue 221 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 64) chain A residue 249 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 65) chain A residue 271 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 66) chain B residue 19 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 67) chain B residue 164 type BINDING sequence K description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 68) chain B residue 192 type BINDING sequence V description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 43 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 70) chain A residue 67 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI3 71) chain A residue 127 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 72) chain A residue 193 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 73) chain B residue 43 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 74) chain B residue 67 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI3 75) chain B residue 127 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 76) chain B residue 193 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 77) chain A residue 38-57 type prosite sequence GAYITKSSTLEKREGNPLPR description DHODEHASE_1 Dihydroorotate dehydrogenase signature 1. GayitKSSTlekReGNplPR source prosite : PS00911 78) chain A residue 245-265 type prosite sequence IIGTGGIETGQDAFEHLLCGA description DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIGtGGIeTgqdAfeHLlCGA source prosite : PS00912

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