eF-site ID 1jqv-AB PDB Code 1jqv Chain A, B click to enlarge Title The K213E mutant of Lactococcus lactis Dihydroorotate dehydrogenase A Classification OXIDOREDUCTASE Compound Dihydroorotate dehydrogenase A Source Lactococcus lactis subsp. cremoris (Streptococcus cremoris) (PYRDA_LACLC) Sequence A:  MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAY ITKSSTLEKREGNPLPRYVDLELGSINSMGLPNLGFDYYL DYVLKNQKENAQEGPIFFSIAGMSAAENIAMLKKIQESDF SGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKP LGVKLPPYFDLVHFDIMAEILNQFPLTYVNSVNSIGNGLF IDPEAESVVIKPEDGFGGIGGAYIKPTALANVRAFYTRLK PEIQIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPA IFDRIIKELEEIMNQKGYQSIADFHGKLKSL B:  MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAY ITKSSTLEKREGNPLPRYVDLELGSINSMGLPNLGFDYYL DYVLKNQKENAQEGPIFFSIAGMSAAENIAMLKKIQESDF SGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKP LGVKLPPYFDLVHFDIMAEILNQFPLTYVNSVNSIGNGLF IDPEAESVVIKPEDGFGGIGGAYIKPTALANVRAFYTRLK PEIQIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPA IFDRIIKELEEIMNQKGYQSIADFHGKLKSL Description Functional site 1) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE MG A 314 source : AC1 2) chain A residue 35 type sequence S description BINDING SITE FOR RESIDUE MG A 314 source : AC1 3) chain B residue 33 type sequence K description BINDING SITE FOR RESIDUE MG B 314 source : AC2 4) chain B residue 35 type sequence S description BINDING SITE FOR RESIDUE MG B 314 source : AC2 5) chain A residue 18 type sequence A description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 6) chain A residue 19 type sequence S description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 7) chain A residue 20 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 8) chain A residue 43 type sequence K description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 9) chain A residue 44 type sequence S description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 10) chain A residue 58 type sequence Y description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 11) chain A residue 67 type sequence N description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 12) chain A residue 69 type sequence M description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 13) chain A residue 127 type sequence N description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 14) chain A residue 164 type sequence K description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 15) chain A residue 192 type sequence V description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 16) chain A residue 193 type sequence N description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 17) chain A residue 221 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 18) chain A residue 248 type sequence T description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 19) chain A residue 249 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 20) chain A residue 250 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 21) chain A residue 271 type sequence G description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 22) chain A residue 272 type sequence T description BINDING SITE FOR RESIDUE FMN A 1312 source : AC3 23) chain A residue 43 type sequence K description BINDING SITE FOR RESIDUE ORO A 1313 source : AC4 24) chain A residue 67 type sequence N description BINDING SITE FOR RESIDUE ORO A 1313 source : AC4 25) chain A residue 69 type sequence M description BINDING SITE FOR RESIDUE ORO A 1313 source : AC4 26) chain A residue 70 type sequence G description BINDING SITE FOR RESIDUE ORO A 1313 source : AC4 27) chain A residue 71 type sequence L description BINDING SITE FOR RESIDUE ORO A 1313 source : AC4 28) chain A residue 127 type sequence N description BINDING SITE FOR RESIDUE ORO A 1313 source : AC4 29) chain A residue 193 type sequence N description BINDING SITE FOR RESIDUE ORO A 1313 source : AC4 30) chain A residue 194 type sequence S description BINDING SITE FOR RESIDUE ORO A 1313 source : AC4 31) chain B residue 18 type sequence A description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 32) chain B residue 19 type sequence S description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 33) chain B residue 20 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 34) chain B residue 43 type sequence K description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 35) chain B residue 44 type sequence S description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 36) chain B residue 58 type sequence Y description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 37) chain B residue 67 type sequence N description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 38) chain B residue 69 type sequence M description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 39) chain B residue 127 type sequence N description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 40) chain B residue 164 type sequence K description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 41) chain B residue 192 type sequence V description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 42) chain B residue 193 type sequence N description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 43) chain B residue 221 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 44) chain B residue 248 type sequence T description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 45) chain B residue 249 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 46) chain B residue 250 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 47) chain B residue 271 type sequence G description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 48) chain B residue 272 type sequence T description BINDING SITE FOR RESIDUE FMN B 2312 source : AC5 49) chain B residue 43 type sequence K description BINDING SITE FOR RESIDUE ORO B 2313 source : AC6 50) chain B residue 67 type sequence N description BINDING SITE FOR RESIDUE ORO B 2313 source : AC6 51) chain B residue 69 type sequence M description BINDING SITE FOR RESIDUE ORO B 2313 source : AC6 52) chain B residue 70 type sequence G description BINDING SITE FOR RESIDUE ORO B 2313 source : AC6 53) chain B residue 71 type sequence L description BINDING SITE FOR RESIDUE ORO B 2313 source : AC6 54) chain B residue 127 type sequence N description BINDING SITE FOR RESIDUE ORO B 2313 source : AC6 55) chain B residue 193 type sequence N description BINDING SITE FOR RESIDUE ORO B 2313 source : AC6 56) chain B residue 194 type sequence S description BINDING SITE FOR RESIDUE ORO B 2313 source : AC6 57) chain A residue 213 type sequence E description BINDING SITE FOR RESIDUE ACY A 1001 source : AC7 58) chain A residue 216 type sequence F description BINDING SITE FOR RESIDUE ACY A 1001 source : AC7 59) chain B residue 238 type sequence R description BINDING SITE FOR RESIDUE ACY A 1001 source : AC7 60) chain B residue 129 type sequence S description BINDING SITE FOR RESIDUE ACY B 1002 source : AC8 61) chain B residue 193 type sequence N description BINDING SITE FOR RESIDUE ACY B 1002 source : AC8 62) chain B residue 194 type sequence S description BINDING SITE FOR RESIDUE ACY B 1002 source : AC8 63) chain B residue 218 type sequence G description BINDING SITE FOR RESIDUE ACY B 1002 source : AC8 64) chain A residue 238 type sequence R description BINDING SITE FOR RESIDUE ACY B 1003 source : AC9 65) chain B residue 213 type sequence E description BINDING SITE FOR RESIDUE ACY B 1003 source : AC9 66) chain B residue 216 type sequence F description BINDING SITE FOR RESIDUE ACY B 1003 source : AC9 67) chain A residue 129 type sequence S description BINDING SITE FOR RESIDUE ACY A 1004 source : BC1 68) chain A residue 193 type sequence N description BINDING SITE FOR RESIDUE ACY A 1004 source : BC1 69) chain A residue 194 type sequence S description BINDING SITE FOR RESIDUE ACY A 1004 source : BC1 70) chain A residue 196 type sequence G description BINDING SITE FOR RESIDUE ACY A 1004 source : BC1 71) chain A residue 218 type sequence G description BINDING SITE FOR RESIDUE ACY A 1004 source : BC1 72) chain A residue 43 type catalytic sequence K description 892 source MCSA : MCSA1 73) chain A residue 130 type catalytic sequence C description 892 source MCSA : MCSA1 74) chain B residue 43 type catalytic sequence K description 892 source MCSA : MCSA2 75) chain B residue 130 type catalytic sequence C description 892 source MCSA : MCSA2 76) chain A residue 130 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 77) chain B residue 130 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 78) chain A residue 19 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 79) chain B residue 221 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 80) chain B residue 249 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 81) chain B residue 271 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 82) chain A residue 164 type BINDING sequence K description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 83) chain A residue 192 type BINDING sequence V description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 84) chain A residue 221 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 85) chain A residue 249 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 86) chain A residue 271 type BINDING sequence G description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 87) chain B residue 19 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 88) chain B residue 164 type BINDING sequence K description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 89) chain B residue 192 type BINDING sequence V description BINDING => ECO:0000269|PubMed:9032071, ECO:0000269|PubMed:9655329 source Swiss-Prot : SWS_FT_FI2 90) chain A residue 43 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 91) chain A residue 67 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 92) chain A residue 127 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 93) chain A residue 193 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 94) chain B residue 43 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 95) chain B residue 67 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 96) chain B residue 127 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 97) chain B residue 193 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 98) chain A residue 38-57 type prosite sequence GAYITKSSTLEKREGNPLPR description DHODEHASE_1 Dihydroorotate dehydrogenase signature 1. GayitKSSTlekReGNplPR source prosite : PS00911 99) chain A residue 245-265 type prosite sequence IIGTGGIETGQDAFEHLLCGA description DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIGtGGIeTgqdAfeHLlCGA source prosite : PS00912

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