eF-site ID 1jow-B PDB Code 1jow Chain B click to enlarge Title Crystal structure of a complex of human CDK6 and a viral cyclin Classification CELL CYCLE/TRANSFERASE Compound CYCLIN HOMOLOG Source null (CDK6_HUMAN) Sequence B:  DQQYECVYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPL STIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTL VFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL TSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRK PLFRGSSDVDQLGKILDVIGLPGEEDWPQAFHSKSAQPIE KFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF Description Functional site 1) chain B residue 264 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI8 2) chain B residue 145 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 3) chain B residue 13 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI4 4) chain B residue 24 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 5) chain B residue 49 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI6 6) chain B residue 70 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI6 7) chain B residue 177 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:11828325 source Swiss-Prot : SWS_FT_FI7 8) chain B residue 141-153 type prosite sequence VVHRDLKPQNILV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpqNILV source prosite : PS00108 9) chain B residue 43 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links