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eF-site ID
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1jmj-AB |
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PDB Code
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1jmj |
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Chain
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A, B |
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click to enlarge
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Title
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Crystal Structure of Native Heparin Cofactor II |
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Classification
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BLOOD CLOTTING |
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Compound
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HEPARIN COFACTOR II |
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Source
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ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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A: |
LDLEKIFSEDDLQLFHGKSRIQRLNILNAKFAFNLYRVLK
DQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILH
FKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVN
DLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKT
NNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK
FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDC
DILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQ
KSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNG
NMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMP
LSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS
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| B: |
ILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIF
IAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSK
YEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPI
LLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKG
LIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHN
FRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG
ISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREV
LLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRI
AIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVD
RPFLFLIYEHRTSCLLFMGRVANPSRS
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Description
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Functional site
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1)
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chain |
A |
| residue |
368 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12169660
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| source |
Swiss-Prot : SWS_FT_FI6
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2)
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chain |
B |
| residue |
368 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12169660
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| source |
Swiss-Prot : SWS_FT_FI6
|
|
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3)
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chain |
B |
| residue |
444 |
| type |
SITE |
| sequence |
L
|
| description |
Reactive bond => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
A |
| residue |
444 |
| type |
SITE |
| sequence |
L
|
| description |
Reactive bond => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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5)
|
chain |
B |
| residue |
169 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12169660, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
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6)
|
chain |
A |
| residue |
169 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12169660, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218
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| source |
Swiss-Prot : SWS_FT_FI5
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7)
|
chain |
A |
| residue |
450-460 |
| type |
prosite |
| sequence |
FTVDRPFLFLI
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| description |
SERPIN Serpins signature. FTVDRPFLFlI
|
| source |
prosite : PS00284
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