eF-site ID 1jlg-AB
PDB Code 1jlg
Chain A, B

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Title CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
Classification TRANSFERASE
Compound HIV-1 RT A-chain
Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2)
Sequence A:  ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEM
EKEGKISKIGPENPYNTPVFAIKKKLVDFRELNKRTQDFW
EVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYT
AFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKIL
EPFRKQNPDIVIYQYMDDLXVGSDLEIGQHRTKIEELRQH
LLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPE
KDSWTVNDIQKLVGKLNWASQIYPGIKVRQLXKLLRGTKA
LTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAE
IQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQL
TEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQA
TWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANR
ETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQD
SGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKK
EKVYLAWVPAH
B:  ETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEG
KISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQ
DFWGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTA
FTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILE
PFRKQNPDIVIYQYMDDLCVGSDLEIGQHRTKIEELRQHL
LRWGELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWAS
QIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENRE
ILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKN
LKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPK
FKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQ
LEKEP
Description


Functional site

1) chain A
residue 100
type
sequence L
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

2) chain A
residue 101
type
sequence K
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

3) chain A
residue 179
type
sequence V
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

4) chain A
residue 181
type
sequence Y
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

5) chain A
residue 188
type
sequence X
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

6) chain A
residue 190
type
sequence G
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

7) chain A
residue 227
type
sequence F
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

8) chain A
residue 234
type
sequence L
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

9) chain A
residue 236
type
sequence P
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

10) chain A
residue 318
type
sequence Y
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC1

11) chain B
residue 111
type BINDING
sequence V
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

12) chain B
residue 186
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

13) chain B
residue 187
type BINDING
sequence L
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 499
type SITE
sequence S
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

15) chain B
residue 402
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

16) chain B
residue 415
type SITE
sequence E
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

17) chain A
residue 402
type SITE
sequence W
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

18) chain A
residue 415
type SITE
sequence E
description Essential for RT p66/p51 heterodimerization => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

19) chain A
residue 441
type SITE
sequence Y
description Cleavage; by viral protease; partial => ECO:0000250
source Swiss-Prot : SWS_FT_FI6


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