eF-site ID 1jlg-A PDB Code 1jlg Chain A click to enlarge Title CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781 Classification TRANSFERASE Compound HIV-1 RT A-chain Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) Sequence A:  ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEM EKEGKISKIGPENPYNTPVFAIKKKLVDFRELNKRTQDFW EVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYT AFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKIL EPFRKQNPDIVIYQYMDDLXVGSDLEIGQHRTKIEELRQH LLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPE KDSWTVNDIQKLVGKLNWASQIYPGIKVRQLXKLLRGTKA LTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAE IQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQL TEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQA TWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANR ETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQD SGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKK EKVYLAWVPAH Description Functional site 1) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 2) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 3) chain A residue 179 type sequence V description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 4) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 5) chain A residue 188 type sequence X description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 6) chain A residue 190 type sequence G description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 7) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 8) chain A residue 234 type sequence L description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 9) chain A residue 236 type sequence P description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 10) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE UC1 A 999 source : AC1 11) chain A residue 402 type SITE sequence W description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 12) chain A residue 415 type SITE sequence E description Essential for RT p66/p51 heterodimerization => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 13) chain A residue 499 type SITE sequence S description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 441 type SITE sequence Y description Cleavage; by viral protease; partial => ECO:0000250 source Swiss-Prot : SWS_FT_FI6

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