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eF-site ID
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1jle-B |
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PDB Code
|
1jle |
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Chain
|
B |
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click to enlarge
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Title
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CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE |
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Classification
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TRANSFERASE |
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Compound
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HIV-1 RT, A-CHAIN |
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Source
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Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) |
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Sequence
|
B: |
PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEK
EGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKR
TQDFQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRK
YTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTK
ILEPFRKQNPDIVIYQYMDDLCVGSDLEIGQHRTKIEELR
QHLLRWELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNW
ASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAEN
REILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPF
KNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKT
PKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLW
YQLEKEPI
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Description
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Functional site
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1)
|
chain |
B |
| residue |
111 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
B |
| residue |
186 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
B |
| residue |
187 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
402 |
| type |
SITE |
| sequence |
W
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
B |
| residue |
415 |
| type |
SITE |
| sequence |
E
|
| description |
Essential for RT p66/p51 heterodimerization => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
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